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Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis

Chlamydia psittaci is an established zoonotic agent causing respiratory disease in humans. An infection often remains asymptomatic but can also result in flu-like illness, pneumonia or even multi-organ failure. This paper describes three patients, hospitalised at AZ Sint-Lucas Hospital, with atypica...

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Autores principales: Missault, Sophie, De Meyst, Anne, Van Elslande, Jan, Van den Abeele, Anne-Marie, Steen, Elke, Van Acker, Jos, Vanrompay, Daisy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861199/
https://www.ncbi.nlm.nih.gov/pubmed/36678414
http://dx.doi.org/10.3390/pathogens12010065
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author Missault, Sophie
De Meyst, Anne
Van Elslande, Jan
Van den Abeele, Anne-Marie
Steen, Elke
Van Acker, Jos
Vanrompay, Daisy
author_facet Missault, Sophie
De Meyst, Anne
Van Elslande, Jan
Van den Abeele, Anne-Marie
Steen, Elke
Van Acker, Jos
Vanrompay, Daisy
author_sort Missault, Sophie
collection PubMed
description Chlamydia psittaci is an established zoonotic agent causing respiratory disease in humans. An infection often remains asymptomatic but can also result in flu-like illness, pneumonia or even multi-organ failure. This paper describes three patients, hospitalised at AZ Sint-Lucas Hospital, with atypical pneumonia who were diagnosed with C. psittaci after an in-depth anamnesis and laboratory investigation in the midst of the COVID pandemic. All three infections were confirmed with PCR and serology, whereas viable bacteria were only present for one patient. Genotyping revealed the presence of genotype B for patient 1 and 2 whereas ompA genotyping was unsuccessful for patient 3. This case report demonstrates the importance of a thorough patient history as close contact with birds is one of the main risk factors to contract the pathogen. Once exposure to birds has been confirmed, a diagnosis by a combination of PCR and serology is essential in order to initiate a treatment with the proper antibiotics. As psittacosis is still an underestimated and underdiagnosed disease, communication between laboratory, clinicians and bird fanciers is encouraged.
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spelling pubmed-98611992023-01-22 Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis Missault, Sophie De Meyst, Anne Van Elslande, Jan Van den Abeele, Anne-Marie Steen, Elke Van Acker, Jos Vanrompay, Daisy Pathogens Case Report Chlamydia psittaci is an established zoonotic agent causing respiratory disease in humans. An infection often remains asymptomatic but can also result in flu-like illness, pneumonia or even multi-organ failure. This paper describes three patients, hospitalised at AZ Sint-Lucas Hospital, with atypical pneumonia who were diagnosed with C. psittaci after an in-depth anamnesis and laboratory investigation in the midst of the COVID pandemic. All three infections were confirmed with PCR and serology, whereas viable bacteria were only present for one patient. Genotyping revealed the presence of genotype B for patient 1 and 2 whereas ompA genotyping was unsuccessful for patient 3. This case report demonstrates the importance of a thorough patient history as close contact with birds is one of the main risk factors to contract the pathogen. Once exposure to birds has been confirmed, a diagnosis by a combination of PCR and serology is essential in order to initiate a treatment with the proper antibiotics. As psittacosis is still an underestimated and underdiagnosed disease, communication between laboratory, clinicians and bird fanciers is encouraged. MDPI 2022-12-31 /pmc/articles/PMC9861199/ /pubmed/36678414 http://dx.doi.org/10.3390/pathogens12010065 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Missault, Sophie
De Meyst, Anne
Van Elslande, Jan
Van den Abeele, Anne-Marie
Steen, Elke
Van Acker, Jos
Vanrompay, Daisy
Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis
title Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis
title_full Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis
title_fullStr Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis
title_full_unstemmed Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis
title_short Three Cases of Atypical Pneumonia with Chlamydia psittaci: The Role of Laboratory Vigilance in the Diagnosis of Psittacosis
title_sort three cases of atypical pneumonia with chlamydia psittaci: the role of laboratory vigilance in the diagnosis of psittacosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861199/
https://www.ncbi.nlm.nih.gov/pubmed/36678414
http://dx.doi.org/10.3390/pathogens12010065
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