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miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis

Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is diagnosed for the first time during pregnancy. The objective of this study is to know the glucose tolerance status after 15 years of pregnancy in patients diagnosed with gestational diabetes and to assess the...

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Autores principales: Ares Blanco, Jessica, Lambert, Carmen, Fernandez-Sanjurjo, Manuel, Morales-Sanchez, Paula, Pujante, Pedro, Pinto-Hernández, Paola, Iglesias-Gutiérrez, Eduardo, Menendez Torre, Edelmiro, Delgado, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861277/
https://www.ncbi.nlm.nih.gov/pubmed/36674679
http://dx.doi.org/10.3390/ijms24021152
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author Ares Blanco, Jessica
Lambert, Carmen
Fernandez-Sanjurjo, Manuel
Morales-Sanchez, Paula
Pujante, Pedro
Pinto-Hernández, Paola
Iglesias-Gutiérrez, Eduardo
Menendez Torre, Edelmiro
Delgado, Elias
author_facet Ares Blanco, Jessica
Lambert, Carmen
Fernandez-Sanjurjo, Manuel
Morales-Sanchez, Paula
Pujante, Pedro
Pinto-Hernández, Paola
Iglesias-Gutiérrez, Eduardo
Menendez Torre, Edelmiro
Delgado, Elias
author_sort Ares Blanco, Jessica
collection PubMed
description Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is diagnosed for the first time during pregnancy. The objective of this study is to know the glucose tolerance status after 15 years of pregnancy in patients diagnosed with gestational diabetes and to assess the long-term effect of GDM on the circulating miRNA profile of these women. To answer these, 30 randomly selected women diagnosed with GDM during 2005–2006 were included in the study, and glucose tolerance was measured using the National Diabetes Data Group criteria. Additionally, four miRNAs (hsa-miR-1-3p, hsa-miR-24-3p, hsa-miR-329-3p, hsa-miR-543) were selected for their analysis in the plasma of women 15 years after the diagnosis of GDM. In our study we discovered that, fifteen years after the diagnosis of GDM, 50% of women have some degree of glucose intolerance directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed a significantly increased level of circulating hsa-miR-24-3p. Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
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spelling pubmed-98612772023-01-22 miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis Ares Blanco, Jessica Lambert, Carmen Fernandez-Sanjurjo, Manuel Morales-Sanchez, Paula Pujante, Pedro Pinto-Hernández, Paola Iglesias-Gutiérrez, Eduardo Menendez Torre, Edelmiro Delgado, Elias Int J Mol Sci Article Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is diagnosed for the first time during pregnancy. The objective of this study is to know the glucose tolerance status after 15 years of pregnancy in patients diagnosed with gestational diabetes and to assess the long-term effect of GDM on the circulating miRNA profile of these women. To answer these, 30 randomly selected women diagnosed with GDM during 2005–2006 were included in the study, and glucose tolerance was measured using the National Diabetes Data Group criteria. Additionally, four miRNAs (hsa-miR-1-3p, hsa-miR-24-3p, hsa-miR-329-3p, hsa-miR-543) were selected for their analysis in the plasma of women 15 years after the diagnosis of GDM. In our study we discovered that, fifteen years after the diagnosis of GDM, 50% of women have some degree of glucose intolerance directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed a significantly increased level of circulating hsa-miR-24-3p. Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM. MDPI 2023-01-06 /pmc/articles/PMC9861277/ /pubmed/36674679 http://dx.doi.org/10.3390/ijms24021152 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ares Blanco, Jessica
Lambert, Carmen
Fernandez-Sanjurjo, Manuel
Morales-Sanchez, Paula
Pujante, Pedro
Pinto-Hernández, Paola
Iglesias-Gutiérrez, Eduardo
Menendez Torre, Edelmiro
Delgado, Elias
miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis
title miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis
title_full miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis
title_fullStr miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis
title_full_unstemmed miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis
title_short miR-24-3p and Body Mass Index as Type 2 Diabetes Risk Factors in Spanish Women 15 Years after Gestational Diabetes Mellitus Diagnosis
title_sort mir-24-3p and body mass index as type 2 diabetes risk factors in spanish women 15 years after gestational diabetes mellitus diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861277/
https://www.ncbi.nlm.nih.gov/pubmed/36674679
http://dx.doi.org/10.3390/ijms24021152
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