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Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme

(1) Background: Eudraguard(®) Natural (EN) and Protect (EP) are polymers regulated for use in dietary supplements in the European Union and the United States to carry natural products, mask unpleasant smells and tastes, ameliorate product handling, and protect products from moisture, light, and oxid...

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Autores principales: Lauro, Maria Rosaria, Picerno, Patrizia, Franceschelli, Silvia, Pecoraro, Michela, Aquino, Rita Patrizia, Pignatello, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861284/
https://www.ncbi.nlm.nih.gov/pubmed/36678923
http://dx.doi.org/10.3390/pharmaceutics15010295
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author Lauro, Maria Rosaria
Picerno, Patrizia
Franceschelli, Silvia
Pecoraro, Michela
Aquino, Rita Patrizia
Pignatello, Rosario
author_facet Lauro, Maria Rosaria
Picerno, Patrizia
Franceschelli, Silvia
Pecoraro, Michela
Aquino, Rita Patrizia
Pignatello, Rosario
author_sort Lauro, Maria Rosaria
collection PubMed
description (1) Background: Eudraguard(®) Natural (EN) and Protect (EP) are polymers regulated for use in dietary supplements in the European Union and the United States to carry natural products, mask unpleasant smells and tastes, ameliorate product handling, and protect products from moisture, light, and oxidation. Moreover, EN and EP can control the release of encapsulated compounds. The aim of this work was the development, preparation, and control of Eudraguard(®) spray-drying microparticles to obtain powders with easy handling and a stable dietary supplement containing a polar functional extract (SOE) from Sorbus domestica L. leaves. (2) Methods: SOE was characterized using HPLC, NMR, FTIR, DSC, and SEM methods. Furthermore, the SOE’s antioxidant/free radical scavenging activity, α-glucosidase inhibition, MTT assay effect on viability in normal cells, and shelf life were evaluated in both the extract and final formulations. (3) Results: The data suggested that SOE, rich in flavonoids, is a bioactive and safe extract; however, from a technological point of view, it was sticky, difficult to handle, and had low aqueous solubility. Despite the fact that EN and EP may undergo changes with spray-drying, they effectively produced easy-to-handle micro-powders with a controlled release profile. Although EN had a weaker capability to coat SOE than EP, EN acted as a substrate that was able to swell, drawing in water and improving the extract solubility and dissolution/release; however, EP was also able to carry the extract and provide SOE with controlled release. (4) Conclusion: Both Eudraguard(®) products were capable of carrying SOE and improving its antioxidant and α-glucosidase inhibition activities, as well as the extract stability and handling.
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spelling pubmed-98612842023-01-22 Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme Lauro, Maria Rosaria Picerno, Patrizia Franceschelli, Silvia Pecoraro, Michela Aquino, Rita Patrizia Pignatello, Rosario Pharmaceutics Article (1) Background: Eudraguard(®) Natural (EN) and Protect (EP) are polymers regulated for use in dietary supplements in the European Union and the United States to carry natural products, mask unpleasant smells and tastes, ameliorate product handling, and protect products from moisture, light, and oxidation. Moreover, EN and EP can control the release of encapsulated compounds. The aim of this work was the development, preparation, and control of Eudraguard(®) spray-drying microparticles to obtain powders with easy handling and a stable dietary supplement containing a polar functional extract (SOE) from Sorbus domestica L. leaves. (2) Methods: SOE was characterized using HPLC, NMR, FTIR, DSC, and SEM methods. Furthermore, the SOE’s antioxidant/free radical scavenging activity, α-glucosidase inhibition, MTT assay effect on viability in normal cells, and shelf life were evaluated in both the extract and final formulations. (3) Results: The data suggested that SOE, rich in flavonoids, is a bioactive and safe extract; however, from a technological point of view, it was sticky, difficult to handle, and had low aqueous solubility. Despite the fact that EN and EP may undergo changes with spray-drying, they effectively produced easy-to-handle micro-powders with a controlled release profile. Although EN had a weaker capability to coat SOE than EP, EN acted as a substrate that was able to swell, drawing in water and improving the extract solubility and dissolution/release; however, EP was also able to carry the extract and provide SOE with controlled release. (4) Conclusion: Both Eudraguard(®) products were capable of carrying SOE and improving its antioxidant and α-glucosidase inhibition activities, as well as the extract stability and handling. MDPI 2023-01-16 /pmc/articles/PMC9861284/ /pubmed/36678923 http://dx.doi.org/10.3390/pharmaceutics15010295 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lauro, Maria Rosaria
Picerno, Patrizia
Franceschelli, Silvia
Pecoraro, Michela
Aquino, Rita Patrizia
Pignatello, Rosario
Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme
title Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme
title_full Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme
title_fullStr Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme
title_full_unstemmed Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme
title_short Eudraguard(®) Natural and Protect: New “Food Grade” Matrices for the Delivery of an Extract from Sorbus domestica L. Leaves Active on the α-Glucosidase Enzyme
title_sort eudraguard(®) natural and protect: new “food grade” matrices for the delivery of an extract from sorbus domestica l. leaves active on the α-glucosidase enzyme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861284/
https://www.ncbi.nlm.nih.gov/pubmed/36678923
http://dx.doi.org/10.3390/pharmaceutics15010295
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