Cargando…
A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection
Radiotherapy is now recognized as a pillar in the fight against cancer. Two different types are currently used in clinical practice: (1) external beam radiotherapy, using high-energy X-rays or electron beams, both in the MeV-range, and (2) intraoperative radiotherapy, using low-energy X-rays (up to...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861322/ https://www.ncbi.nlm.nih.gov/pubmed/36676560 http://dx.doi.org/10.3390/ma16020824 |
_version_ | 1784874812398632960 |
---|---|
author | Pettinato, Sara Girolami, Marco Stravato, Antonella Serpente, Valerio Musio, Daniela Rossi, Maria C. Trucchi, Daniele M. Olivieri, Riccardo Salvatori, Stefano |
author_facet | Pettinato, Sara Girolami, Marco Stravato, Antonella Serpente, Valerio Musio, Daniela Rossi, Maria C. Trucchi, Daniele M. Olivieri, Riccardo Salvatori, Stefano |
author_sort | Pettinato, Sara |
collection | PubMed |
description | Radiotherapy is now recognized as a pillar in the fight against cancer. Two different types are currently used in clinical practice: (1) external beam radiotherapy, using high-energy X-rays or electron beams, both in the MeV-range, and (2) intraoperative radiotherapy, using low-energy X-rays (up to 50 keV) and MeV-range electron beams. Versatile detectors able to measure the radiation dose independently from the radiation nature and energy are therefore extremely appealing to medical physicists. In this work, a dosimeter based on a high-quality single-crystal synthetic diamond sample was designed, fabricated and characterized under low-energy X-rays, as well as under high-energy pulsed X-rays and electron beams, demonstrating excellent linearity with radiation dose and dose-rate. Detector sensitivity was measured to be 0.299 ± 0.002 µC/Gy under 6 MeV X-ray photons, and 0.298 ± 0.004 µC/Gy under 6 MeV electrons, highlighting that the response of the diamond dosimeter is independent of the radiation nature. Moreover, in the case of low-energy X-rays, an extremely low limit of detection (23 nGy/s) was evaluated, pointing out the suitability of the device to radiation protection dosimetry. |
format | Online Article Text |
id | pubmed-9861322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98613222023-01-22 A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection Pettinato, Sara Girolami, Marco Stravato, Antonella Serpente, Valerio Musio, Daniela Rossi, Maria C. Trucchi, Daniele M. Olivieri, Riccardo Salvatori, Stefano Materials (Basel) Article Radiotherapy is now recognized as a pillar in the fight against cancer. Two different types are currently used in clinical practice: (1) external beam radiotherapy, using high-energy X-rays or electron beams, both in the MeV-range, and (2) intraoperative radiotherapy, using low-energy X-rays (up to 50 keV) and MeV-range electron beams. Versatile detectors able to measure the radiation dose independently from the radiation nature and energy are therefore extremely appealing to medical physicists. In this work, a dosimeter based on a high-quality single-crystal synthetic diamond sample was designed, fabricated and characterized under low-energy X-rays, as well as under high-energy pulsed X-rays and electron beams, demonstrating excellent linearity with radiation dose and dose-rate. Detector sensitivity was measured to be 0.299 ± 0.002 µC/Gy under 6 MeV X-ray photons, and 0.298 ± 0.004 µC/Gy under 6 MeV electrons, highlighting that the response of the diamond dosimeter is independent of the radiation nature. Moreover, in the case of low-energy X-rays, an extremely low limit of detection (23 nGy/s) was evaluated, pointing out the suitability of the device to radiation protection dosimetry. MDPI 2023-01-14 /pmc/articles/PMC9861322/ /pubmed/36676560 http://dx.doi.org/10.3390/ma16020824 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pettinato, Sara Girolami, Marco Stravato, Antonella Serpente, Valerio Musio, Daniela Rossi, Maria C. Trucchi, Daniele M. Olivieri, Riccardo Salvatori, Stefano A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection |
title | A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection |
title_full | A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection |
title_fullStr | A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection |
title_full_unstemmed | A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection |
title_short | A Highly Versatile X-ray and Electron Beam Diamond Dosimeter for Radiation Therapy and Protection |
title_sort | highly versatile x-ray and electron beam diamond dosimeter for radiation therapy and protection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861322/ https://www.ncbi.nlm.nih.gov/pubmed/36676560 http://dx.doi.org/10.3390/ma16020824 |
work_keys_str_mv | AT pettinatosara ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT girolamimarco ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT stravatoantonella ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT serpentevalerio ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT musiodaniela ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT rossimariac ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT trucchidanielem ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT olivieririccardo ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT salvatoristefano ahighlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT pettinatosara highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT girolamimarco highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT stravatoantonella highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT serpentevalerio highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT musiodaniela highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT rossimariac highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT trucchidanielem highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT olivieririccardo highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection AT salvatoristefano highlyversatilexrayandelectronbeamdiamonddosimeterforradiationtherapyandprotection |