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Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader
Chameleonicity (the capacity of a molecule to adapt its conformations to the environment) may help to identify orally bioavailable drugs in the beyond-Rule-of-5 chemical space. Computational methods to predict the chameleonic behaviour of degraders have not yet been reported and the identification o...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861353/ https://www.ncbi.nlm.nih.gov/pubmed/36678900 http://dx.doi.org/10.3390/pharmaceutics15010272 |