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Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure
Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861363/ https://www.ncbi.nlm.nih.gov/pubmed/36678312 http://dx.doi.org/10.3390/nu15020441 |
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author | Rossholt, Madelaine Eloranta Wendel, Kristina Bratlie, Marianne Aas, Marlen Fossan Gunnarsdottir, Gunnthorunn Fugelseth, Drude Pripp, Are Hugo Domellöf, Magnus Størdal, Ketil Stiris, Tom Moltu, Sissel Jennifer |
author_facet | Rossholt, Madelaine Eloranta Wendel, Kristina Bratlie, Marianne Aas, Marlen Fossan Gunnarsdottir, Gunnthorunn Fugelseth, Drude Pripp, Are Hugo Domellöf, Magnus Størdal, Ketil Stiris, Tom Moltu, Sissel Jennifer |
author_sort | Rossholt, Madelaine Eloranta |
collection | PubMed |
description | Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A concentrations in blood. We report detailed information on vitamin A biochemistry, vitamin A intake, markers of inflammation and dexamethasone exposure. After four weeks of age, infants exposed to dexamethasone (n = 39) showed higher vitamin A concentrations compared to unexposed infants (n = 41); median (IQR) retinol was 1.0 (0.74, 1.5) vs. 0.56 (0.41, 0.74) µmol/L, p < 0.001. Pretreatment retinol concentrations were lower in the dexamethasone group compared to non-exposed infants (p < 0.001); 88% vs. 60% of the infants were considered deficient in vitamin A (retinol < 0.7 µmol/L) at one week of age. Small size for gestational age, mechanical ventilation and elevated levels of interleukin-6 were factors negatively associated with first-week retinol concentrations. In conclusion, preterm infants <29 weeks gestation are at risk of vitamin A deficiency despite intakes that accommodate current recommendations. The presence of inflammation and dexamethasone exposure should be considered when interpreting vitamin A status. |
format | Online Article Text |
id | pubmed-9861363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98613632023-01-22 Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure Rossholt, Madelaine Eloranta Wendel, Kristina Bratlie, Marianne Aas, Marlen Fossan Gunnarsdottir, Gunnthorunn Fugelseth, Drude Pripp, Are Hugo Domellöf, Magnus Størdal, Ketil Stiris, Tom Moltu, Sissel Jennifer Nutrients Article Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A concentrations in blood. We report detailed information on vitamin A biochemistry, vitamin A intake, markers of inflammation and dexamethasone exposure. After four weeks of age, infants exposed to dexamethasone (n = 39) showed higher vitamin A concentrations compared to unexposed infants (n = 41); median (IQR) retinol was 1.0 (0.74, 1.5) vs. 0.56 (0.41, 0.74) µmol/L, p < 0.001. Pretreatment retinol concentrations were lower in the dexamethasone group compared to non-exposed infants (p < 0.001); 88% vs. 60% of the infants were considered deficient in vitamin A (retinol < 0.7 µmol/L) at one week of age. Small size for gestational age, mechanical ventilation and elevated levels of interleukin-6 were factors negatively associated with first-week retinol concentrations. In conclusion, preterm infants <29 weeks gestation are at risk of vitamin A deficiency despite intakes that accommodate current recommendations. The presence of inflammation and dexamethasone exposure should be considered when interpreting vitamin A status. MDPI 2023-01-14 /pmc/articles/PMC9861363/ /pubmed/36678312 http://dx.doi.org/10.3390/nu15020441 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rossholt, Madelaine Eloranta Wendel, Kristina Bratlie, Marianne Aas, Marlen Fossan Gunnarsdottir, Gunnthorunn Fugelseth, Drude Pripp, Are Hugo Domellöf, Magnus Størdal, Ketil Stiris, Tom Moltu, Sissel Jennifer Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
title | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
title_full | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
title_fullStr | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
title_full_unstemmed | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
title_short | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
title_sort | vitamin a status in preterm infants is associated with inflammation and dexamethasone exposure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861363/ https://www.ncbi.nlm.nih.gov/pubmed/36678312 http://dx.doi.org/10.3390/nu15020441 |
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