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Sleep Deprivation Increases Facial Skin Yellowness
Sleep shortage is a major concern in modern life and induces various psycho-physical disorders, including skin problems. In cosmeceutics, females are aware that sleep deprivation worsens their facial skin tone. Here, we measured the effects of sleep deprivation on facial skin yellowness and examined...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861417/ https://www.ncbi.nlm.nih.gov/pubmed/36675544 http://dx.doi.org/10.3390/jcm12020615 |
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author | Matsubara, Akira Deng, Gang Gong, Lili Chew, Eileen Furue, Masutaka Xu, Ying Fang, Bin Hakozaki, Tomohiro |
author_facet | Matsubara, Akira Deng, Gang Gong, Lili Chew, Eileen Furue, Masutaka Xu, Ying Fang, Bin Hakozaki, Tomohiro |
author_sort | Matsubara, Akira |
collection | PubMed |
description | Sleep shortage is a major concern in modern life and induces various psycho-physical disorders, including skin problems. In cosmeceutics, females are aware that sleep deprivation worsens their facial skin tone. Here, we measured the effects of sleep deprivation on facial skin yellowness and examined yellow chromophores, such as bilirubin and carotenoids, in blood serum as potential causes of yellowness. Total sleep deprivation (0 h sleep overnight, N = 28) and repeated partial sleep deprivation (4 h sleep for 5 consecutive days, N = 10) induced significant increases in facial skin yellowness. The higher yellowness was sustained even after both sleep deprivation types stopped. However, circulating levels of yellow chromophores were unchanged in the total sleep deprivation study. Neither circulating interleukin-6 nor urinary biopyrrin levels were affected by total sleep deprivation, suggesting that apparent oxidative stress in the body was not detected in the present total deprivation protocol. Facial redness was affected by neither total nor repeated partial sleep deprivation. Therefore, blood circulation may play a limited role in elevated yellowness. In conclusion, facial skin yellowness was indeed increased by sleep deprivation in our clinical studies. Local in situ skin-derived factors, rather than systemic chromophore change, may contribute to the sleep deprivation-induced elevation of facial skin yellowness. |
format | Online Article Text |
id | pubmed-9861417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98614172023-01-22 Sleep Deprivation Increases Facial Skin Yellowness Matsubara, Akira Deng, Gang Gong, Lili Chew, Eileen Furue, Masutaka Xu, Ying Fang, Bin Hakozaki, Tomohiro J Clin Med Article Sleep shortage is a major concern in modern life and induces various psycho-physical disorders, including skin problems. In cosmeceutics, females are aware that sleep deprivation worsens their facial skin tone. Here, we measured the effects of sleep deprivation on facial skin yellowness and examined yellow chromophores, such as bilirubin and carotenoids, in blood serum as potential causes of yellowness. Total sleep deprivation (0 h sleep overnight, N = 28) and repeated partial sleep deprivation (4 h sleep for 5 consecutive days, N = 10) induced significant increases in facial skin yellowness. The higher yellowness was sustained even after both sleep deprivation types stopped. However, circulating levels of yellow chromophores were unchanged in the total sleep deprivation study. Neither circulating interleukin-6 nor urinary biopyrrin levels were affected by total sleep deprivation, suggesting that apparent oxidative stress in the body was not detected in the present total deprivation protocol. Facial redness was affected by neither total nor repeated partial sleep deprivation. Therefore, blood circulation may play a limited role in elevated yellowness. In conclusion, facial skin yellowness was indeed increased by sleep deprivation in our clinical studies. Local in situ skin-derived factors, rather than systemic chromophore change, may contribute to the sleep deprivation-induced elevation of facial skin yellowness. MDPI 2023-01-12 /pmc/articles/PMC9861417/ /pubmed/36675544 http://dx.doi.org/10.3390/jcm12020615 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Matsubara, Akira Deng, Gang Gong, Lili Chew, Eileen Furue, Masutaka Xu, Ying Fang, Bin Hakozaki, Tomohiro Sleep Deprivation Increases Facial Skin Yellowness |
title | Sleep Deprivation Increases Facial Skin Yellowness |
title_full | Sleep Deprivation Increases Facial Skin Yellowness |
title_fullStr | Sleep Deprivation Increases Facial Skin Yellowness |
title_full_unstemmed | Sleep Deprivation Increases Facial Skin Yellowness |
title_short | Sleep Deprivation Increases Facial Skin Yellowness |
title_sort | sleep deprivation increases facial skin yellowness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861417/ https://www.ncbi.nlm.nih.gov/pubmed/36675544 http://dx.doi.org/10.3390/jcm12020615 |
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