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Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model

A controlled-neonatal piglet trial was conducted to evaluate the impact of a plant-based infant formula containing buckwheat and almonds as the main source of protein compared to a commercially available dairy-based formula on the gut health parameters. Two day old piglets were fed either a plant-ba...

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Autores principales: Gurung, Manoj, Rosa, Fernanda, Yelvington, Brooke, Terry, Nathan, Read, Quentin D., Piccolo, Brian D., Moody, Becky, Tripp, Patricia, Pittman, Hoy E., Fay, Bobby L., Ross, Talyor J., Sikes, James D., Flowers, Jessica B., Fox, Renee, LeRoith, Tanya, Talatala, Rachelanne, Bar-Yoseph, Fabiana, Yeruva, Laxmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861483/
https://www.ncbi.nlm.nih.gov/pubmed/36678256
http://dx.doi.org/10.3390/nu15020383
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author Gurung, Manoj
Rosa, Fernanda
Yelvington, Brooke
Terry, Nathan
Read, Quentin D.
Piccolo, Brian D.
Moody, Becky
Tripp, Patricia
Pittman, Hoy E.
Fay, Bobby L.
Ross, Talyor J.
Sikes, James D.
Flowers, Jessica B.
Fox, Renee
LeRoith, Tanya
Talatala, Rachelanne
Bar-Yoseph, Fabiana
Yeruva, Laxmi
author_facet Gurung, Manoj
Rosa, Fernanda
Yelvington, Brooke
Terry, Nathan
Read, Quentin D.
Piccolo, Brian D.
Moody, Becky
Tripp, Patricia
Pittman, Hoy E.
Fay, Bobby L.
Ross, Talyor J.
Sikes, James D.
Flowers, Jessica B.
Fox, Renee
LeRoith, Tanya
Talatala, Rachelanne
Bar-Yoseph, Fabiana
Yeruva, Laxmi
author_sort Gurung, Manoj
collection PubMed
description A controlled-neonatal piglet trial was conducted to evaluate the impact of a plant-based infant formula containing buckwheat and almonds as the main source of protein compared to a commercially available dairy-based formula on the gut health parameters. Two day old piglets were fed either a plant-based or a dairy-based formula until day 21. Gut microbiome, cytokines, growth and metabolism related outcomes, and intestinal morphology were evaluated to determine the safety of the plant-based infant formula. This study reported that the plant-based formula-fed piglets had a similar intestinal microbiota composition relative to the dairy-based formula-fed group. However, differential abundance of specific microbiota species was detected within each diet group in the small and large intestinal regions and fecal samples. Lactobacillus delbrueckii, Lactobacillus crispatus, and Fusobacterium sp. had higher abundance in the small intestine of plant-based formula-fed piglets compared to the dairy-based group. Bacteroides nordii, Enterococcus sp., Lactobacillus crispatus, Prevotella sp., Ruminococcus lactaris, Bacteroides nordii, Eisenbergiella sp., Lactobacillus crispatus, Prevotella sp., and Akkermansia muciniphila had greater abundance in the large intestine of the plant based diet fed piglets relative to the dairy-based diet group. In the feces, Clostridiales, Bacteroides uniformis, Butyricimonasvirosa, Cloacibacillus porcorum, Clostridium clostridioforme, and Fusobacterium sp. were abundant in dairy-based group relative to the plant-based group. Lachnospiraceae, Clostridium scindens, Lactobacillus coleohominis, and Prevetolla sp. had greater abundance in the feces of the plant-based group in comparison to the dairy-based group. Gut morphology was similar between the plant and the dairy-based formula-fed piglets. Circulatory cytokines, magnesium, triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), vitamin D, vitamin K, and IgE levels were similar among all piglets independent of dietary group. Overall, the present study demonstrated that a plant-based formula with buckwheat and almonds as the primary source of protein can support similar gut microbiota growth and health outcomes compared to a dairy-based infant formula.
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spelling pubmed-98614832023-01-22 Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model Gurung, Manoj Rosa, Fernanda Yelvington, Brooke Terry, Nathan Read, Quentin D. Piccolo, Brian D. Moody, Becky Tripp, Patricia Pittman, Hoy E. Fay, Bobby L. Ross, Talyor J. Sikes, James D. Flowers, Jessica B. Fox, Renee LeRoith, Tanya Talatala, Rachelanne Bar-Yoseph, Fabiana Yeruva, Laxmi Nutrients Article A controlled-neonatal piglet trial was conducted to evaluate the impact of a plant-based infant formula containing buckwheat and almonds as the main source of protein compared to a commercially available dairy-based formula on the gut health parameters. Two day old piglets were fed either a plant-based or a dairy-based formula until day 21. Gut microbiome, cytokines, growth and metabolism related outcomes, and intestinal morphology were evaluated to determine the safety of the plant-based infant formula. This study reported that the plant-based formula-fed piglets had a similar intestinal microbiota composition relative to the dairy-based formula-fed group. However, differential abundance of specific microbiota species was detected within each diet group in the small and large intestinal regions and fecal samples. Lactobacillus delbrueckii, Lactobacillus crispatus, and Fusobacterium sp. had higher abundance in the small intestine of plant-based formula-fed piglets compared to the dairy-based group. Bacteroides nordii, Enterococcus sp., Lactobacillus crispatus, Prevotella sp., Ruminococcus lactaris, Bacteroides nordii, Eisenbergiella sp., Lactobacillus crispatus, Prevotella sp., and Akkermansia muciniphila had greater abundance in the large intestine of the plant based diet fed piglets relative to the dairy-based diet group. In the feces, Clostridiales, Bacteroides uniformis, Butyricimonasvirosa, Cloacibacillus porcorum, Clostridium clostridioforme, and Fusobacterium sp. were abundant in dairy-based group relative to the plant-based group. Lachnospiraceae, Clostridium scindens, Lactobacillus coleohominis, and Prevetolla sp. had greater abundance in the feces of the plant-based group in comparison to the dairy-based group. Gut morphology was similar between the plant and the dairy-based formula-fed piglets. Circulatory cytokines, magnesium, triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), vitamin D, vitamin K, and IgE levels were similar among all piglets independent of dietary group. Overall, the present study demonstrated that a plant-based formula with buckwheat and almonds as the primary source of protein can support similar gut microbiota growth and health outcomes compared to a dairy-based infant formula. MDPI 2023-01-12 /pmc/articles/PMC9861483/ /pubmed/36678256 http://dx.doi.org/10.3390/nu15020383 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gurung, Manoj
Rosa, Fernanda
Yelvington, Brooke
Terry, Nathan
Read, Quentin D.
Piccolo, Brian D.
Moody, Becky
Tripp, Patricia
Pittman, Hoy E.
Fay, Bobby L.
Ross, Talyor J.
Sikes, James D.
Flowers, Jessica B.
Fox, Renee
LeRoith, Tanya
Talatala, Rachelanne
Bar-Yoseph, Fabiana
Yeruva, Laxmi
Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
title Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
title_full Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
title_fullStr Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
title_full_unstemmed Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
title_short Evaluation of a Plant-Based Infant Formula Containing Almonds and Buckwheat on Gut Microbiota Composition, Intestine Morphology, Metabolic and Immune Markers in a Neonatal Piglet Model
title_sort evaluation of a plant-based infant formula containing almonds and buckwheat on gut microbiota composition, intestine morphology, metabolic and immune markers in a neonatal piglet model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861483/
https://www.ncbi.nlm.nih.gov/pubmed/36678256
http://dx.doi.org/10.3390/nu15020383
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