Cargando…
Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases
Background: Lomentospora prolificans, a rare, highly virulent filamentous fungus with high rates of intrinsic resistance to antifungals, has been associated with different types of infections in immunocompromised as well as immunocompetent individuals. Objective: To systematically address all releva...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861501/ https://www.ncbi.nlm.nih.gov/pubmed/36678415 http://dx.doi.org/10.3390/pathogens12010067 |
_version_ | 1784874857291317248 |
---|---|
author | Konsoula, Afroditi Agouridis, Aris P. Markaki, Lamprini Tsioutis, Constantinos Spernovasilis, Nikolaos |
author_facet | Konsoula, Afroditi Agouridis, Aris P. Markaki, Lamprini Tsioutis, Constantinos Spernovasilis, Nikolaos |
author_sort | Konsoula, Afroditi |
collection | PubMed |
description | Background: Lomentospora prolificans, a rare, highly virulent filamentous fungus with high rates of intrinsic resistance to antifungals, has been associated with different types of infections in immunocompromised as well as immunocompetent individuals. Objective: To systematically address all relevant evidence regarding L. prolificans disseminated infections in the literature. Methods: We searched Medline via PubMed and Scopus databases through July 2022. We performed a qualitative synthesis of published articles reporting disseminated infections from L. prolificans in humans. Results: A total of 87 studies describing 142 cases were included in our systematic review. The pathogen was most frequently reported in disseminated infections in Spain (n = 47), Australia (n = 33), the USA (n = 21), and Germany (n = 10). Among 142 reported cases, 48.5% were males. Underlying conditions identified for the majority of patients included malignancy (72.5%), hemopoietic stem cell transplantation (23.2%), solid organ transplantation (16%), and AIDS (2%). Lungs, central nervous system, skin, eyes, heart and bones/joints were the most commonly affected organs. Neutropenia was recorded in 52% of patients. The mortality rate was as high as 87.3%. Conclusions: To the best of our knowledge, this is the first systematic review conducted on disseminated infections due to this rare microorganism. Physicians should be aware that L. prolificans can cause a diversity of infections with high mortality and primarily affects immunocompromised and neutropenic patients. |
format | Online Article Text |
id | pubmed-9861501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98615012023-01-22 Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases Konsoula, Afroditi Agouridis, Aris P. Markaki, Lamprini Tsioutis, Constantinos Spernovasilis, Nikolaos Pathogens Systematic Review Background: Lomentospora prolificans, a rare, highly virulent filamentous fungus with high rates of intrinsic resistance to antifungals, has been associated with different types of infections in immunocompromised as well as immunocompetent individuals. Objective: To systematically address all relevant evidence regarding L. prolificans disseminated infections in the literature. Methods: We searched Medline via PubMed and Scopus databases through July 2022. We performed a qualitative synthesis of published articles reporting disseminated infections from L. prolificans in humans. Results: A total of 87 studies describing 142 cases were included in our systematic review. The pathogen was most frequently reported in disseminated infections in Spain (n = 47), Australia (n = 33), the USA (n = 21), and Germany (n = 10). Among 142 reported cases, 48.5% were males. Underlying conditions identified for the majority of patients included malignancy (72.5%), hemopoietic stem cell transplantation (23.2%), solid organ transplantation (16%), and AIDS (2%). Lungs, central nervous system, skin, eyes, heart and bones/joints were the most commonly affected organs. Neutropenia was recorded in 52% of patients. The mortality rate was as high as 87.3%. Conclusions: To the best of our knowledge, this is the first systematic review conducted on disseminated infections due to this rare microorganism. Physicians should be aware that L. prolificans can cause a diversity of infections with high mortality and primarily affects immunocompromised and neutropenic patients. MDPI 2022-12-31 /pmc/articles/PMC9861501/ /pubmed/36678415 http://dx.doi.org/10.3390/pathogens12010067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Konsoula, Afroditi Agouridis, Aris P. Markaki, Lamprini Tsioutis, Constantinos Spernovasilis, Nikolaos Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases |
title | Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases |
title_full | Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases |
title_fullStr | Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases |
title_full_unstemmed | Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases |
title_short | Lomentospora prolificans Disseminated Infections: A Systematic Review of Reported Cases |
title_sort | lomentospora prolificans disseminated infections: a systematic review of reported cases |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861501/ https://www.ncbi.nlm.nih.gov/pubmed/36678415 http://dx.doi.org/10.3390/pathogens12010067 |
work_keys_str_mv | AT konsoulaafroditi lomentosporaprolificansdisseminatedinfectionsasystematicreviewofreportedcases AT agouridisarisp lomentosporaprolificansdisseminatedinfectionsasystematicreviewofreportedcases AT markakilamprini lomentosporaprolificansdisseminatedinfectionsasystematicreviewofreportedcases AT tsioutisconstantinos lomentosporaprolificansdisseminatedinfectionsasystematicreviewofreportedcases AT spernovasilisnikolaos lomentosporaprolificansdisseminatedinfectionsasystematicreviewofreportedcases |