Cargando…

Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives

Many scientists are working hard to find green alternatives to classical synthetic methods. Today, state-of-the-art ultrasonic and grinding techniques already drive the production of organic compounds on an industrial scale. The physicochemical and chemical behavior of cyclodextrins often differs fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Jicsinszky, László, Rossi, Federica, Solarino, Roberto, Cravotto, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861519/
https://www.ncbi.nlm.nih.gov/pubmed/36677527
http://dx.doi.org/10.3390/molecules28020467
_version_ 1784874861732036608
author Jicsinszky, László
Rossi, Federica
Solarino, Roberto
Cravotto, Giancarlo
author_facet Jicsinszky, László
Rossi, Federica
Solarino, Roberto
Cravotto, Giancarlo
author_sort Jicsinszky, László
collection PubMed
description Many scientists are working hard to find green alternatives to classical synthetic methods. Today, state-of-the-art ultrasonic and grinding techniques already drive the production of organic compounds on an industrial scale. The physicochemical and chemical behavior of cyclodextrins often differs from the typical properties of classic organic compounds and carbohydrates. The usually poor solubility and complexing properties of cyclodextrins can require special techniques. By eliminating or reducing the amount of solvent needed, green alternatives can reform classical synthetic methods, making them attractive for environmentally friendly production and the circular economy. The lack of energy-intensive synthetic and purification steps could transform currently inefficient processes into feasible methods. Mechanochemical reaction mechanisms are generally different from normal solution-chemistry mechanisms. The absence of a solvent and the presence of very high local temperatures for microseconds facilitate the synthesis of cyclodextrin derivatives that are impossible or difficult to produce under classical solution-chemistry conditions. Although mechanochemistry does not provide a general solution to all problems, several good examples show that this new technology can open up efficient synthetic pathways.
format Online
Article
Text
id pubmed-9861519
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98615192023-01-22 Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives Jicsinszky, László Rossi, Federica Solarino, Roberto Cravotto, Giancarlo Molecules Review Many scientists are working hard to find green alternatives to classical synthetic methods. Today, state-of-the-art ultrasonic and grinding techniques already drive the production of organic compounds on an industrial scale. The physicochemical and chemical behavior of cyclodextrins often differs from the typical properties of classic organic compounds and carbohydrates. The usually poor solubility and complexing properties of cyclodextrins can require special techniques. By eliminating or reducing the amount of solvent needed, green alternatives can reform classical synthetic methods, making them attractive for environmentally friendly production and the circular economy. The lack of energy-intensive synthetic and purification steps could transform currently inefficient processes into feasible methods. Mechanochemical reaction mechanisms are generally different from normal solution-chemistry mechanisms. The absence of a solvent and the presence of very high local temperatures for microseconds facilitate the synthesis of cyclodextrin derivatives that are impossible or difficult to produce under classical solution-chemistry conditions. Although mechanochemistry does not provide a general solution to all problems, several good examples show that this new technology can open up efficient synthetic pathways. MDPI 2023-01-04 /pmc/articles/PMC9861519/ /pubmed/36677527 http://dx.doi.org/10.3390/molecules28020467 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jicsinszky, László
Rossi, Federica
Solarino, Roberto
Cravotto, Giancarlo
Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives
title Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives
title_full Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives
title_fullStr Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives
title_full_unstemmed Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives
title_short Comparison of the Conventional and Mechanochemical Syntheses of Cyclodextrin Derivatives
title_sort comparison of the conventional and mechanochemical syntheses of cyclodextrin derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861519/
https://www.ncbi.nlm.nih.gov/pubmed/36677527
http://dx.doi.org/10.3390/molecules28020467
work_keys_str_mv AT jicsinszkylaszlo comparisonoftheconventionalandmechanochemicalsynthesesofcyclodextrinderivatives
AT rossifederica comparisonoftheconventionalandmechanochemicalsynthesesofcyclodextrinderivatives
AT solarinoroberto comparisonoftheconventionalandmechanochemicalsynthesesofcyclodextrinderivatives
AT cravottogiancarlo comparisonoftheconventionalandmechanochemicalsynthesesofcyclodextrinderivatives