Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT

The metabolic basis of Parkinson’s disease pathology is poorly understood. However, the involvement of mitochondrial and endoplasmic reticulum stress in dopamine neurons in disease aetiology is well established. We looked at the effect of rotenone- and tunicamycin-induced mitochondrial and ER stress...

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Detalles Bibliográficos
Autores principales: Fernandes, Hugo J. R., Kent, Josh P., Bruntraeger, Michaela, Bassett, Andrew R., Koulman, Albert, Metzakopian, Emmanouil, Snowden, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861589/
https://www.ncbi.nlm.nih.gov/pubmed/36677037
http://dx.doi.org/10.3390/metabo13010112

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