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An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology
Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Due to the high therapeutic potential of Vaccinium myrtillus (VM) leaves, this review aims to present the latest knowledge on the phytochemical profile, as well as the therapeutic effects of t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861616/ https://www.ncbi.nlm.nih.gov/pubmed/36678645 http://dx.doi.org/10.3390/pharmaceutics15010016 |
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author | Ștefănescu, Ruxandra Laczkó-Zöld, Eszter Ősz, Bianca-Eugenia Vari, Camil-Eugen |
author_facet | Ștefănescu, Ruxandra Laczkó-Zöld, Eszter Ősz, Bianca-Eugenia Vari, Camil-Eugen |
author_sort | Ștefănescu, Ruxandra |
collection | PubMed |
description | Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Due to the high therapeutic potential of Vaccinium myrtillus (VM) leaves, this review aims to present the latest knowledge on the phytochemical profile, as well as the therapeutic effects of this herbal drug. The review was conducted according to the Prisma guidelines, and the scientific databases were searched using combinations of the following keywords: “Vaccinium myrtillus”, “leaves”, “bilberry”. Recent research was focused on the influence of abiotic factors on the phytochemical composition, and it seems that there are significant differences between the herbal drugs collected from different countries. The phytochemical composition is correlated with the broad spectrum of pharmacological effects. The paper outlines the potent antimicrobial activity of VM extracts against multidrug-resistant bacterial strains, and also the pathways that are modulated by the unique “cocktail” of phytoconstituents in different metabolic alterations. Reviewing the research articles published in the last 10 years, it seems that bilberry leaves have been slightly forgotten, although their phytochemical and pharmacological characteristics are unique. |
format | Online Article Text |
id | pubmed-9861616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98616162023-01-22 An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology Ștefănescu, Ruxandra Laczkó-Zöld, Eszter Ősz, Bianca-Eugenia Vari, Camil-Eugen Pharmaceutics Review Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Due to the high therapeutic potential of Vaccinium myrtillus (VM) leaves, this review aims to present the latest knowledge on the phytochemical profile, as well as the therapeutic effects of this herbal drug. The review was conducted according to the Prisma guidelines, and the scientific databases were searched using combinations of the following keywords: “Vaccinium myrtillus”, “leaves”, “bilberry”. Recent research was focused on the influence of abiotic factors on the phytochemical composition, and it seems that there are significant differences between the herbal drugs collected from different countries. The phytochemical composition is correlated with the broad spectrum of pharmacological effects. The paper outlines the potent antimicrobial activity of VM extracts against multidrug-resistant bacterial strains, and also the pathways that are modulated by the unique “cocktail” of phytoconstituents in different metabolic alterations. Reviewing the research articles published in the last 10 years, it seems that bilberry leaves have been slightly forgotten, although their phytochemical and pharmacological characteristics are unique. MDPI 2022-12-21 /pmc/articles/PMC9861616/ /pubmed/36678645 http://dx.doi.org/10.3390/pharmaceutics15010016 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ștefănescu, Ruxandra Laczkó-Zöld, Eszter Ősz, Bianca-Eugenia Vari, Camil-Eugen An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology |
title | An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology |
title_full | An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology |
title_fullStr | An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology |
title_full_unstemmed | An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology |
title_short | An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology |
title_sort | updated systematic review of vaccinium myrtillus leaves: phytochemistry and pharmacology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861616/ https://www.ncbi.nlm.nih.gov/pubmed/36678645 http://dx.doi.org/10.3390/pharmaceutics15010016 |
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