Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?

Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence exc...

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Autores principales: Di Somma, Carolina, Scarano, Elisabetta, Arianna, Rossana, Romano, Fiammetta, Lavorgna, Mariarosaria, Serpico, Domenico, Colao, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861672/
https://www.ncbi.nlm.nih.gov/pubmed/36675591
http://dx.doi.org/10.3390/jcm12020662
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author Di Somma, Carolina
Scarano, Elisabetta
Arianna, Rossana
Romano, Fiammetta
Lavorgna, Mariarosaria
Serpico, Domenico
Colao, Annamaria
author_facet Di Somma, Carolina
Scarano, Elisabetta
Arianna, Rossana
Romano, Fiammetta
Lavorgna, Mariarosaria
Serpico, Domenico
Colao, Annamaria
author_sort Di Somma, Carolina
collection PubMed
description Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors.
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spelling pubmed-98616722023-01-22 Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk? Di Somma, Carolina Scarano, Elisabetta Arianna, Rossana Romano, Fiammetta Lavorgna, Mariarosaria Serpico, Domenico Colao, Annamaria J Clin Med Review Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors. MDPI 2023-01-13 /pmc/articles/PMC9861672/ /pubmed/36675591 http://dx.doi.org/10.3390/jcm12020662 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Somma, Carolina
Scarano, Elisabetta
Arianna, Rossana
Romano, Fiammetta
Lavorgna, Mariarosaria
Serpico, Domenico
Colao, Annamaria
Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
title Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
title_full Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
title_fullStr Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
title_full_unstemmed Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
title_short Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
title_sort long-term safety of growth hormone deficiency treatment in cancer and sellar tumors adult survivors: is there a role of gh therapy on the neoplastic risk?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861672/
https://www.ncbi.nlm.nih.gov/pubmed/36675591
http://dx.doi.org/10.3390/jcm12020662
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