Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers

Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects are the main limitations of peripheral delive...

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Detalles Bibliográficos
Autores principales: Cárdenas, Graciela, Bobes, Raúl J., Fragoso, Gladis, Pérez-Osorio, Nicolas I., Hernández, Marisela, Espinosa, Alejandro, Fleury, Agnes, Flores, José, Laclette, Juan Pedro, Sciutto, Edda, Jung-Cook, Helgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861764/
https://www.ncbi.nlm.nih.gov/pubmed/36678735
http://dx.doi.org/10.3390/pharmaceutics15010105

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