Advancements in Cancer Immunotherapies

Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to...

Descripción completa

Detalles Bibliográficos
Autores principales: Roy, Ruchi, Singh, Sunil Kumar, Misra, Sweta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861770/
https://www.ncbi.nlm.nih.gov/pubmed/36679904
http://dx.doi.org/10.3390/vaccines11010059
_version_ 1784874924776620032
author Roy, Ruchi
Singh, Sunil Kumar
Misra, Sweta
author_facet Roy, Ruchi
Singh, Sunil Kumar
Misra, Sweta
author_sort Roy, Ruchi
collection PubMed
description Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical trials. Therefore, this article focuses on the therapeutic approaches and developmental strategies to treat cancer. This review emphasizes the immunomodulatory response, the involvement of key tumor-infiltrating cells, the mechanistic aspects, and prognostic biomarkers. We also cover recent advancements in therapeutic strategies.
format Online
Article
Text
id pubmed-9861770
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98617702023-01-22 Advancements in Cancer Immunotherapies Roy, Ruchi Singh, Sunil Kumar Misra, Sweta Vaccines (Basel) Review Recent work has suggested involvement of the immune system in biological therapies specifically targeting tumor microenvironment. Substantial advancement in the treatment of malignant tumors utilizing immune cells, most importantly T cells that play a key role in cell-mediated immunity, have led to success in clinical trials. Therefore, this article focuses on the therapeutic approaches and developmental strategies to treat cancer. This review emphasizes the immunomodulatory response, the involvement of key tumor-infiltrating cells, the mechanistic aspects, and prognostic biomarkers. We also cover recent advancements in therapeutic strategies. MDPI 2022-12-27 /pmc/articles/PMC9861770/ /pubmed/36679904 http://dx.doi.org/10.3390/vaccines11010059 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roy, Ruchi
Singh, Sunil Kumar
Misra, Sweta
Advancements in Cancer Immunotherapies
title Advancements in Cancer Immunotherapies
title_full Advancements in Cancer Immunotherapies
title_fullStr Advancements in Cancer Immunotherapies
title_full_unstemmed Advancements in Cancer Immunotherapies
title_short Advancements in Cancer Immunotherapies
title_sort advancements in cancer immunotherapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861770/
https://www.ncbi.nlm.nih.gov/pubmed/36679904
http://dx.doi.org/10.3390/vaccines11010059
work_keys_str_mv AT royruchi advancementsincancerimmunotherapies
AT singhsunilkumar advancementsincancerimmunotherapies
AT misrasweta advancementsincancerimmunotherapies

Ejemplares similares