Cargando…

Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults

Triacylglycerols (TG) play an important role in skin homeostasis including the synthesis of ω-O-acylceramides (acylCER) required for skin barrier formation by providing linoleic acid (C18:2n6). However, the overall relationships of TG species with various ceramides (CER) including CER-NP, the most a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Ju-Young, Jeon, Sanghun, Han, Sangshin, Liu, Kwang-Hyeon, Cho, Yunhi, Kim, Kun-Pyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861786/
https://www.ncbi.nlm.nih.gov/pubmed/36676956
http://dx.doi.org/10.3390/metabo13010031
_version_ 1784874928758063104
author Lee, Ju-Young
Jeon, Sanghun
Han, Sangshin
Liu, Kwang-Hyeon
Cho, Yunhi
Kim, Kun-Pyo
author_facet Lee, Ju-Young
Jeon, Sanghun
Han, Sangshin
Liu, Kwang-Hyeon
Cho, Yunhi
Kim, Kun-Pyo
author_sort Lee, Ju-Young
collection PubMed
description Triacylglycerols (TG) play an important role in skin homeostasis including the synthesis of ω-O-acylceramides (acylCER) required for skin barrier formation by providing linoleic acid (C18:2n6). However, the overall relationships of TG species with various ceramides (CER) including CER-NP, the most abundant CER, ω-O-acylCER, and another acylCER, 1-O-acylCER in human SC, remain unclear. Therefore, we investigated these relationships and their influence on skin health status in healthy Korean adults. Twelve CER subclasses including two ω-O-acylCER and two 1-O-acylCER were identified with CER-NP consisting of approximately half of the total CER. The ω-O-acylCER species exhibited positive relationships with TG 52:4 and TG 54:2 containing C18:2, while interestingly, 1-O-acylCER containing ester-linked C14:0 and C16:0 demonstrated positive relationships with TG 46–50 including C14:0 and C16:0, respectively. In addition, CER-NP and CER-NH showed positive correlations with TG 52–54 containing C18:2 or C18:3. A lipid pattern with higher levels of CER including CER-NP and ω-O-acylCER with TG 54 and TG with 5–6 double bonds was related to good skin health status, especially with acidic skin pH. Collectively, TG with increased chain length and unsaturation seemed to improve CER content, and profiles such as higher acylCER and CER-NP improved skin health status by fortifying skin barrier structure.
format Online
Article
Text
id pubmed-9861786
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98617862023-01-22 Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults Lee, Ju-Young Jeon, Sanghun Han, Sangshin Liu, Kwang-Hyeon Cho, Yunhi Kim, Kun-Pyo Metabolites Article Triacylglycerols (TG) play an important role in skin homeostasis including the synthesis of ω-O-acylceramides (acylCER) required for skin barrier formation by providing linoleic acid (C18:2n6). However, the overall relationships of TG species with various ceramides (CER) including CER-NP, the most abundant CER, ω-O-acylCER, and another acylCER, 1-O-acylCER in human SC, remain unclear. Therefore, we investigated these relationships and their influence on skin health status in healthy Korean adults. Twelve CER subclasses including two ω-O-acylCER and two 1-O-acylCER were identified with CER-NP consisting of approximately half of the total CER. The ω-O-acylCER species exhibited positive relationships with TG 52:4 and TG 54:2 containing C18:2, while interestingly, 1-O-acylCER containing ester-linked C14:0 and C16:0 demonstrated positive relationships with TG 46–50 including C14:0 and C16:0, respectively. In addition, CER-NP and CER-NH showed positive correlations with TG 52–54 containing C18:2 or C18:3. A lipid pattern with higher levels of CER including CER-NP and ω-O-acylCER with TG 54 and TG with 5–6 double bonds was related to good skin health status, especially with acidic skin pH. Collectively, TG with increased chain length and unsaturation seemed to improve CER content, and profiles such as higher acylCER and CER-NP improved skin health status by fortifying skin barrier structure. MDPI 2022-12-24 /pmc/articles/PMC9861786/ /pubmed/36676956 http://dx.doi.org/10.3390/metabo13010031 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Ju-Young
Jeon, Sanghun
Han, Sangshin
Liu, Kwang-Hyeon
Cho, Yunhi
Kim, Kun-Pyo
Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults
title Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults
title_full Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults
title_fullStr Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults
title_full_unstemmed Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults
title_short Positive Correlation of Triacylglycerols with Increased Chain Length and Unsaturation with ω-O-Acylceramide and Ceramide-NP as Well as Acidic pH in the Skin Surface of Healthy Korean Adults
title_sort positive correlation of triacylglycerols with increased chain length and unsaturation with ω-o-acylceramide and ceramide-np as well as acidic ph in the skin surface of healthy korean adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861786/
https://www.ncbi.nlm.nih.gov/pubmed/36676956
http://dx.doi.org/10.3390/metabo13010031
work_keys_str_mv AT leejuyoung positivecorrelationoftriacylglycerolswithincreasedchainlengthandunsaturationwithōoacylceramideandceramidenpaswellasacidicphintheskinsurfaceofhealthykoreanadults
AT jeonsanghun positivecorrelationoftriacylglycerolswithincreasedchainlengthandunsaturationwithōoacylceramideandceramidenpaswellasacidicphintheskinsurfaceofhealthykoreanadults
AT hansangshin positivecorrelationoftriacylglycerolswithincreasedchainlengthandunsaturationwithōoacylceramideandceramidenpaswellasacidicphintheskinsurfaceofhealthykoreanadults
AT liukwanghyeon positivecorrelationoftriacylglycerolswithincreasedchainlengthandunsaturationwithōoacylceramideandceramidenpaswellasacidicphintheskinsurfaceofhealthykoreanadults
AT choyunhi positivecorrelationoftriacylglycerolswithincreasedchainlengthandunsaturationwithōoacylceramideandceramidenpaswellasacidicphintheskinsurfaceofhealthykoreanadults
AT kimkunpyo positivecorrelationoftriacylglycerolswithincreasedchainlengthandunsaturationwithōoacylceramideandceramidenpaswellasacidicphintheskinsurfaceofhealthykoreanadults