Cargando…
Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women
(1) Background: Streptococcus agalactiae or Group B Streptococcus (GBS) causes severe neonatal infections with a high burden of disease, especially in Africa. Maternal vaginal colonization and perinatal transmissions represent the common mode of acquiring the infection. Development of an effective m...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861799/ https://www.ncbi.nlm.nih.gov/pubmed/36677330 http://dx.doi.org/10.3390/microorganisms11010038 |
_version_ | 1784874931901693952 |
---|---|
author | Shabayek, Sarah Vogel, Verena Jamrozy, Dorota Bentley, Stephen D. Spellerberg, Barbara |
author_facet | Shabayek, Sarah Vogel, Verena Jamrozy, Dorota Bentley, Stephen D. Spellerberg, Barbara |
author_sort | Shabayek, Sarah |
collection | PubMed |
description | (1) Background: Streptococcus agalactiae or Group B Streptococcus (GBS) causes severe neonatal infections with a high burden of disease, especially in Africa. Maternal vaginal colonization and perinatal transmissions represent the common mode of acquiring the infection. Development of an effective maternal vaccine against GBS relies on molecular surveillance of the maternal GBS population to better understand the global distribution of GBS clones and serotypes. (2) Methods: Here, we present genomic data from a collection of colonizing GBS strains from Ismailia, Egypt that were sequenced and characterized within the global JUNO project. (3) Results: A large proportion of serotype VI, ST14 strains was discovered, a serotype which is rarely found in strain collections from the US and Europe and typically not included in the current vaccine formulations. (4) Conclusions: The molecular epidemiology of these strains clearly points to the African origin with the detection of several sequence types (STs) that have only been observed in Africa. Our data underline the importance of continuous molecular surveillance of the GBS population for future vaccine implementations. |
format | Online Article Text |
id | pubmed-9861799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98617992023-01-22 Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women Shabayek, Sarah Vogel, Verena Jamrozy, Dorota Bentley, Stephen D. Spellerberg, Barbara Microorganisms Article (1) Background: Streptococcus agalactiae or Group B Streptococcus (GBS) causes severe neonatal infections with a high burden of disease, especially in Africa. Maternal vaginal colonization and perinatal transmissions represent the common mode of acquiring the infection. Development of an effective maternal vaccine against GBS relies on molecular surveillance of the maternal GBS population to better understand the global distribution of GBS clones and serotypes. (2) Methods: Here, we present genomic data from a collection of colonizing GBS strains from Ismailia, Egypt that were sequenced and characterized within the global JUNO project. (3) Results: A large proportion of serotype VI, ST14 strains was discovered, a serotype which is rarely found in strain collections from the US and Europe and typically not included in the current vaccine formulations. (4) Conclusions: The molecular epidemiology of these strains clearly points to the African origin with the detection of several sequence types (STs) that have only been observed in Africa. Our data underline the importance of continuous molecular surveillance of the GBS population for future vaccine implementations. MDPI 2022-12-22 /pmc/articles/PMC9861799/ /pubmed/36677330 http://dx.doi.org/10.3390/microorganisms11010038 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shabayek, Sarah Vogel, Verena Jamrozy, Dorota Bentley, Stephen D. Spellerberg, Barbara Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women |
title | Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women |
title_full | Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women |
title_fullStr | Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women |
title_full_unstemmed | Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women |
title_short | Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women |
title_sort | molecular epidemiology of group b streptococcus colonization in egyptian women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861799/ https://www.ncbi.nlm.nih.gov/pubmed/36677330 http://dx.doi.org/10.3390/microorganisms11010038 |
work_keys_str_mv | AT shabayeksarah molecularepidemiologyofgroupbstreptococcuscolonizationinegyptianwomen AT vogelverena molecularepidemiologyofgroupbstreptococcuscolonizationinegyptianwomen AT jamrozydorota molecularepidemiologyofgroupbstreptococcuscolonizationinegyptianwomen AT bentleystephend molecularepidemiologyofgroupbstreptococcuscolonizationinegyptianwomen AT spellerbergbarbara molecularepidemiologyofgroupbstreptococcuscolonizationinegyptianwomen |