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Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress

Anthocyanin is a natural antioxidant agent extracted from the fruits of Sambucus canadensis, which has been considered to have potential anti-aging effects. Cell senescence is the primary cause of aging and related diseases. Recently, research on the development of compounds for eliminating senescen...

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Autores principales: Hu, Xiaoqing, Yang, Yimeng, Tang, Shi, Chen, Qiuyan, Zhang, Meiyu, Ma, Jiaoyan, Qin, Jianchun, Yu, Huimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861870/
https://www.ncbi.nlm.nih.gov/pubmed/36675036
http://dx.doi.org/10.3390/ijms24021528
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author Hu, Xiaoqing
Yang, Yimeng
Tang, Shi
Chen, Qiuyan
Zhang, Meiyu
Ma, Jiaoyan
Qin, Jianchun
Yu, Huimei
author_facet Hu, Xiaoqing
Yang, Yimeng
Tang, Shi
Chen, Qiuyan
Zhang, Meiyu
Ma, Jiaoyan
Qin, Jianchun
Yu, Huimei
author_sort Hu, Xiaoqing
collection PubMed
description Anthocyanin is a natural antioxidant agent extracted from the fruits of Sambucus canadensis, which has been considered to have potential anti-aging effects. Cell senescence is the primary cause of aging and related diseases. Recently, research on the development of compounds for eliminating senescent cells or damaged organs have shown prospects. The compounds which promote the clearing of senescent cells are called “senolytics”. Though anthocyanin is considered to have potential anti-aging effects owing to its anti-inflammatory and antioxidant activities, the mechanism of the elimination of senescent cells remains unclear. In this study, we prepared anthocyanins extracted from the fruits of Sambucus canadensis and evaluated their anti-aging effects in vivo and in vitro. We found that anthocyanin could significantly reduce cell senescence and aging of the lens by inhibiting the activity of the PI3K/AKT/mTOR signaling pathway, consequently promoting the apoptosis of senescent cells, increasing the autophagic and mitophagic flux, and enhancing the renewal of mitochondria and the cell to maintain cellular homeostasis, leading to attenuating aging. Therefore, our study provided a basis for anthocyanin to be used as new “senolytics” in anti-aging.
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spelling pubmed-98618702023-01-22 Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress Hu, Xiaoqing Yang, Yimeng Tang, Shi Chen, Qiuyan Zhang, Meiyu Ma, Jiaoyan Qin, Jianchun Yu, Huimei Int J Mol Sci Article Anthocyanin is a natural antioxidant agent extracted from the fruits of Sambucus canadensis, which has been considered to have potential anti-aging effects. Cell senescence is the primary cause of aging and related diseases. Recently, research on the development of compounds for eliminating senescent cells or damaged organs have shown prospects. The compounds which promote the clearing of senescent cells are called “senolytics”. Though anthocyanin is considered to have potential anti-aging effects owing to its anti-inflammatory and antioxidant activities, the mechanism of the elimination of senescent cells remains unclear. In this study, we prepared anthocyanins extracted from the fruits of Sambucus canadensis and evaluated their anti-aging effects in vivo and in vitro. We found that anthocyanin could significantly reduce cell senescence and aging of the lens by inhibiting the activity of the PI3K/AKT/mTOR signaling pathway, consequently promoting the apoptosis of senescent cells, increasing the autophagic and mitophagic flux, and enhancing the renewal of mitochondria and the cell to maintain cellular homeostasis, leading to attenuating aging. Therefore, our study provided a basis for anthocyanin to be used as new “senolytics” in anti-aging. MDPI 2023-01-12 /pmc/articles/PMC9861870/ /pubmed/36675036 http://dx.doi.org/10.3390/ijms24021528 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Xiaoqing
Yang, Yimeng
Tang, Shi
Chen, Qiuyan
Zhang, Meiyu
Ma, Jiaoyan
Qin, Jianchun
Yu, Huimei
Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
title Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
title_full Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
title_fullStr Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
title_full_unstemmed Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
title_short Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
title_sort anti-aging effects of anthocyanin extracts of sambucus canadensis caused by targeting mitochondrial-induced oxidative stress
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861870/
https://www.ncbi.nlm.nih.gov/pubmed/36675036
http://dx.doi.org/10.3390/ijms24021528
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