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Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms

Alginates (ALG) have been used in biomedical and pharmaceutical technologies for decades. ALG are natural polymers occurring in brown algae and feature multiple advantages, including biocompatibility, low toxicity and mucoadhesiveness. Moreover, ALG demonstrate biological activities per se, includin...

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Autores principales: Kruk, Katarzyna, Winnicka, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861938/
https://www.ncbi.nlm.nih.gov/pubmed/36662184
http://dx.doi.org/10.3390/md21010011
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author Kruk, Katarzyna
Winnicka, Katarzyna
author_facet Kruk, Katarzyna
Winnicka, Katarzyna
author_sort Kruk, Katarzyna
collection PubMed
description Alginates (ALG) have been used in biomedical and pharmaceutical technologies for decades. ALG are natural polymers occurring in brown algae and feature multiple advantages, including biocompatibility, low toxicity and mucoadhesiveness. Moreover, ALG demonstrate biological activities per se, including anti-hyperlipidemic, antimicrobial, anti-reflux, immunomodulatory or anti-inflammatory activities. ALG are characterized by gelling ability, one of the most frequently utilized properties in the drug form design. ALG have numerous applications in pharmaceutical technology that include micro- and nanoparticles, tablets, mucoadhesive dosage forms, wound dressings and films. However, there are some shortcomings, which impede the development of modified-release dosage forms or formulations with adequate mechanical strength based on pure ALG. Other natural polymers combined with ALG create great potential as drug carriers, improving limitations of ALG matrices. Therefore, in this paper, ALG blends with pectins, chitosan, gelatin, and carrageenans were critically reviewed.
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spelling pubmed-98619382023-01-22 Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms Kruk, Katarzyna Winnicka, Katarzyna Mar Drugs Review Alginates (ALG) have been used in biomedical and pharmaceutical technologies for decades. ALG are natural polymers occurring in brown algae and feature multiple advantages, including biocompatibility, low toxicity and mucoadhesiveness. Moreover, ALG demonstrate biological activities per se, including anti-hyperlipidemic, antimicrobial, anti-reflux, immunomodulatory or anti-inflammatory activities. ALG are characterized by gelling ability, one of the most frequently utilized properties in the drug form design. ALG have numerous applications in pharmaceutical technology that include micro- and nanoparticles, tablets, mucoadhesive dosage forms, wound dressings and films. However, there are some shortcomings, which impede the development of modified-release dosage forms or formulations with adequate mechanical strength based on pure ALG. Other natural polymers combined with ALG create great potential as drug carriers, improving limitations of ALG matrices. Therefore, in this paper, ALG blends with pectins, chitosan, gelatin, and carrageenans were critically reviewed. MDPI 2022-12-23 /pmc/articles/PMC9861938/ /pubmed/36662184 http://dx.doi.org/10.3390/md21010011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kruk, Katarzyna
Winnicka, Katarzyna
Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms
title Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms
title_full Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms
title_fullStr Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms
title_full_unstemmed Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms
title_short Alginates Combined with Natural Polymers as Valuable Drug Delivery Platforms
title_sort alginates combined with natural polymers as valuable drug delivery platforms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861938/
https://www.ncbi.nlm.nih.gov/pubmed/36662184
http://dx.doi.org/10.3390/md21010011
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