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Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women

A similar abstract of the interim analysis was previously published in Fertility and Sterility. EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT. Uterine fibroids are the most common cause of unexpla...

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Autores principales: Siblini, Hiba, Al-Hendy, Ayman, Segars, James, González, Frank, Taylor, Hugh S., Singh, Bhuchitra, Flaminia, Ainna, Flores, Valerie A., Christman, Gregory M., Huang, Hao, Johnson, Jeremy J., Zhang, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861948/
https://www.ncbi.nlm.nih.gov/pubmed/36678191
http://dx.doi.org/10.3390/nu15020320
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author Siblini, Hiba
Al-Hendy, Ayman
Segars, James
González, Frank
Taylor, Hugh S.
Singh, Bhuchitra
Flaminia, Ainna
Flores, Valerie A.
Christman, Gregory M.
Huang, Hao
Johnson, Jeremy J.
Zhang, Heping
author_facet Siblini, Hiba
Al-Hendy, Ayman
Segars, James
González, Frank
Taylor, Hugh S.
Singh, Bhuchitra
Flaminia, Ainna
Flores, Valerie A.
Christman, Gregory M.
Huang, Hao
Johnson, Jeremy J.
Zhang, Heping
author_sort Siblini, Hiba
collection PubMed
description A similar abstract of the interim analysis was previously published in Fertility and Sterility. EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT. Uterine fibroids are the most common cause of unexplained infertility in reproductive-aged women. Epigallocatechin gallate (EGCG), a green tea catechin, has demonstrated its ability to shrink uterine fibroids in prior preclinical and clinical studies. Hence, we developed an NICHD Confirm-funded trial to evaluate the use of EGCG for treating women with fibroids and unexplained infertility (FRIEND trial). Prior to embarking on that trial, we here conducted the pre-FRIEND study (NCT 04177693) to evaluate the safety of EGCG in premenopausal women. Specifically, our aim was to assess any adverse effects of EGCG alone or in combination with an ovarian stimulator on serum liver function tests (LFTs) and folate level. In this randomized, open-label prospective cohort, participants were recruited from the FRIEND-collaborative clinical sites: Johns Hopkins University, University of Chicago, University of Illinois at Chicago, and Yale University. Thirty-nine women, ages ≥18 to ≤40 years, with/without uterine fibroids, were enrolled and randomized to one of three treatment arms: 800 mg of EGCG daily alone, 800 mg of EGCG daily with clomiphene citrate 100 mg for 5 days, or 800 mg of EGCG daily with Letrozole 5 mg for 5 days. No subject demonstrated signs of drug induced liver injury and no subject showed serum folate level outside the normal range. Hence, our data suggests that a daily dose of 800 mg of EGCG alone or in combination with clomiphene citrate or letrozole (for 5 days) is well-tolerated and is not associated with liver toxicity or folate deficiency in reproductive-aged women.
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spelling pubmed-98619482023-01-22 Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women Siblini, Hiba Al-Hendy, Ayman Segars, James González, Frank Taylor, Hugh S. Singh, Bhuchitra Flaminia, Ainna Flores, Valerie A. Christman, Gregory M. Huang, Hao Johnson, Jeremy J. Zhang, Heping Nutrients Article A similar abstract of the interim analysis was previously published in Fertility and Sterility. EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT. Uterine fibroids are the most common cause of unexplained infertility in reproductive-aged women. Epigallocatechin gallate (EGCG), a green tea catechin, has demonstrated its ability to shrink uterine fibroids in prior preclinical and clinical studies. Hence, we developed an NICHD Confirm-funded trial to evaluate the use of EGCG for treating women with fibroids and unexplained infertility (FRIEND trial). Prior to embarking on that trial, we here conducted the pre-FRIEND study (NCT 04177693) to evaluate the safety of EGCG in premenopausal women. Specifically, our aim was to assess any adverse effects of EGCG alone or in combination with an ovarian stimulator on serum liver function tests (LFTs) and folate level. In this randomized, open-label prospective cohort, participants were recruited from the FRIEND-collaborative clinical sites: Johns Hopkins University, University of Chicago, University of Illinois at Chicago, and Yale University. Thirty-nine women, ages ≥18 to ≤40 years, with/without uterine fibroids, were enrolled and randomized to one of three treatment arms: 800 mg of EGCG daily alone, 800 mg of EGCG daily with clomiphene citrate 100 mg for 5 days, or 800 mg of EGCG daily with Letrozole 5 mg for 5 days. No subject demonstrated signs of drug induced liver injury and no subject showed serum folate level outside the normal range. Hence, our data suggests that a daily dose of 800 mg of EGCG alone or in combination with clomiphene citrate or letrozole (for 5 days) is well-tolerated and is not associated with liver toxicity or folate deficiency in reproductive-aged women. MDPI 2023-01-09 /pmc/articles/PMC9861948/ /pubmed/36678191 http://dx.doi.org/10.3390/nu15020320 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Siblini, Hiba
Al-Hendy, Ayman
Segars, James
González, Frank
Taylor, Hugh S.
Singh, Bhuchitra
Flaminia, Ainna
Flores, Valerie A.
Christman, Gregory M.
Huang, Hao
Johnson, Jeremy J.
Zhang, Heping
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
title Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
title_full Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
title_fullStr Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
title_full_unstemmed Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
title_short Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women
title_sort assessing the hepatic safety of epigallocatechin gallate (egcg) in reproductive-aged women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861948/
https://www.ncbi.nlm.nih.gov/pubmed/36678191
http://dx.doi.org/10.3390/nu15020320
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