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Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review
Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacter...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861949/ https://www.ncbi.nlm.nih.gov/pubmed/36662070 http://dx.doi.org/10.3390/jfb14010023 |
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author | Barreto, Maria E. V. Medeiros, Rebeca P. Shearer, Adam Fook, Marcus V. L. Montazerian, Maziar Mauro, John C. |
author_facet | Barreto, Maria E. V. Medeiros, Rebeca P. Shearer, Adam Fook, Marcus V. L. Montazerian, Maziar Mauro, John C. |
author_sort | Barreto, Maria E. V. |
collection | PubMed |
description | Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds. Searching “bioactive glass gelatin” in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, including the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic responses in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined. |
format | Online Article Text |
id | pubmed-9861949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98619492023-01-22 Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review Barreto, Maria E. V. Medeiros, Rebeca P. Shearer, Adam Fook, Marcus V. L. Montazerian, Maziar Mauro, John C. J Funct Biomater Review Nano-/micron-sized bioactive glass (BG) particles are attractive candidates for both soft and hard tissue engineering. They can chemically bond to the host tissues, enhance new tissue formation, activate cell proliferation, stimulate the genetic expression of proteins, and trigger unique anti-bacterial, anti-inflammatory, and anti-cancer functionalities. Recently, composites based on biopolymers and BG particles have been developed with various state-of-the-art techniques for tissue engineering. Gelatin, a semi-synthetic biopolymer, has attracted the attention of researchers because it is derived from the most abundant protein in the body, viz., collagen. It is a polymer that can be dissolved in water and processed to acquire different configurations, such as hydrogels, fibers, films, and scaffolds. Searching “bioactive glass gelatin” in the tile on Scopus renders 80 highly relevant articles published in the last ~10 years, which signifies the importance of such composites. First, this review addresses the basic concepts of soft and hard tissue engineering, including the healing mechanisms and limitations ahead. Then, current knowledge on gelatin/BG composites including composition, processing and properties is summarized and discussed both for soft and hard tissue applications. This review explores physical, chemical and mechanical features and ion-release effects of such composites concerning osteogenic and angiogenic responses in vivo and in vitro. Additionally, recent developments of BG/gelatin composites using 3D/4D printing for tissue engineering are presented. Finally, the perspectives and current challenges in developing desirable composites for the regeneration of different tissues are outlined. MDPI 2022-12-31 /pmc/articles/PMC9861949/ /pubmed/36662070 http://dx.doi.org/10.3390/jfb14010023 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Barreto, Maria E. V. Medeiros, Rebeca P. Shearer, Adam Fook, Marcus V. L. Montazerian, Maziar Mauro, John C. Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review |
title | Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review |
title_full | Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review |
title_fullStr | Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review |
title_full_unstemmed | Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review |
title_short | Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review |
title_sort | gelatin and bioactive glass composites for tissue engineering: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861949/ https://www.ncbi.nlm.nih.gov/pubmed/36662070 http://dx.doi.org/10.3390/jfb14010023 |
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