Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency

Mitochondrial disorders represent a heterogeneous group of genetic disorders with variations in severity and clinical outcomes, mostly characterized by respiratory chain dysfunction and abnormal mitochondrial function. More specifically, mutations in the human SCO2 gene, encoding the mitochondrial i...

Descripción completa

Detalles Bibliográficos
Autores principales: Miliotou, Androulla N., Foltopoulou, Parthena F., Ingendoh-Tsakmakidis, Alexandra, Tsiftsoglou, Asterios S., Vizirianakis, Ioannis S., Pappas, Ioannis S., Papadopoulou, Lefkothea C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861957/
https://www.ncbi.nlm.nih.gov/pubmed/36678915
http://dx.doi.org/10.3390/pharmaceutics15010286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861957/
https://www.ncbi.nlm.nih.gov/pubmed/36678915
http://dx.doi.org/10.3390/pharmaceutics15010286

Ejemplares similares