Cargando…

Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency

Mitochondrial disorders represent a heterogeneous group of genetic disorders with variations in severity and clinical outcomes, mostly characterized by respiratory chain dysfunction and abnormal mitochondrial function. More specifically, mutations in the human SCO2 gene, encoding the mitochondrial i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miliotou, Androulla N., Foltopoulou, Parthena F., Ingendoh-Tsakmakidis, Alexandra, Tsiftsoglou, Asterios S., Vizirianakis, Ioannis S., Pappas, Ioannis S., Papadopoulou, Lefkothea C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861957/ https://www.ncbi.nlm.nih.gov/pubmed/36678915 http://dx.doi.org/10.3390/pharmaceutics15010286

Ejemplares similares

Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders
por: Miliotou, Androulla N., et al.
Publicado: (2021)

In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations
por: Kaiafas, Georgios C., et al.
Publicado: (2020)

Recruiting In Vitro Transcribed mRNA against Cancer Immunotherapy: A Contemporary Appraisal of the Current Landscape
por: Miliotou, Androulla N., et al.
Publicado: (2023)

PTD-mediated delivery of α-globin chain into Κ-562 erythroleukemia cells and α-thalassemic (HBH) patients’ RBCs ex vivo in the frame of Protein Replacement Therapy
por: Miliotou, Androulla N., et al.
Publicado: (2021)

The Potential Role of Cell Penetrating Peptides in the Intracellular Delivery of Proteins for Therapy of Erythroid Related Disorders
por: Papadopoulou, Lefkothea C., et al.
Publicado: (2013)

An Innovative PTD-IVT-mRNA Delivery Platform for CAR Immunotherapy of ErbB(+) Solid Tumor Neoplastic Cells
por: Georgiou-Siafis, Sofia K., et al.
Publicado: (2022)

mRNA in the Context of Protein Replacement Therapy
por: Vavilis, Theofanis, et al.
Publicado: (2023)

Neural Differentiation of Human Dental Mesenchymal Stem Cells Induced by ATRA and UDP-4: A Comparative Study
por: Koutsoumparis, Anastasios E., et al.
Publicado: (2022)

Mitochondrial Sco proteins are involved in oxidative stress defense
por: Ekim Kocabey, Aslihan, et al.
Publicado: (2018)

Streptomyces coelicolor SCO4226 Is a Nickel Binding Protein
por: Lu, Mo, et al.
Publicado: (2014)

Erythropoietin (EPO) as a Key Regulator of Erythropoiesis, Bone Remodeling and Endothelial Transdifferentiation of Multipotent Mesenchymal Stem Cells (MSCs): Implications in Regenerative Medicine
por: Tsiftsoglou, Asterios S.
Publicado: (2021)

Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor
por: Lalić, Jasna, et al.
Publicado: (2016)

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins
por: Hostachy, Sarah, et al.
Publicado: (2018)

SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity
por: Sepúlveda, Vania, et al.
Publicado: (2021)

Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoV
por: Lokugamage, Kumari G., et al.
Publicado: (2008)

The SCO2102 Protein Harbouring a DnaA II Protein-Interaction Domain Is Essential for the SCO2103 Methylenetetrahydrofolate Reductase Positioning at Streptomyces Sporulating Hyphae, Enhancing DNA Replication during Sporulation
por: Fernández-García, Gemma, et al.
Publicado: (2022)

GATA1 and PU.1 Bind to Ribosomal Protein Genes in Erythroid Cells: Implications for Ribosomopathies
por: Amanatiadou, Elsa P., et al.
Publicado: (2015)

pyScoMotif: discovery of similar 3D structural motifs across proteins
por: Cia, Gabriel, et al.
Publicado: (2023)

In Vitro Effects of Streptococcus oralis Biofilm on Peri-Implant Soft Tissue Cells
por: Ingendoh-Tsakmakidis, Alexandra, et al.
Publicado: (2020)

Sequence variation, common tissue expression patterns and learning models: a genome-wide survey of vertebrate ribosomal proteins
por: Kyritsis, Konstantinos A, et al.
Publicado: (2020)

DySCo: Quantitating Associations of Membrane Proteins Using Two-Color Single-Molecule Tracking
por: Dunne, Paul D., et al.
Publicado: (2009)

Characterization of Plasmodium vivax Early Transcribed Membrane Protein 11.2 and Exported Protein 1
por: Cheng, Yang, et al.
Publicado: (2015)

Modeling of Protein–Protein Interactions in Cytokinin Signal Transduction
por: Arkhipov, Dmitry V., et al.
Publicado: (2019)

The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates
por: Georgiou-Siafis, Sofia K., et al.
Publicado: (2023)

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways
por: Mitsos, Alexander, et al.
Publicado: (2012)

Identification of transcribed protein coding sequence remnants within lincRNAs
por: Talyan, Sweta, et al.
Publicado: (2018)

Identification of novel proteins and mRNAs differentially bound to the Leishmania Poly(A) Binding Proteins reveals a direct association between PABP1, the RNA-binding protein RBP23 and mRNAs encoding ribosomal proteins
por: Assis, Ludmila A., et al.
Publicado: (2021)

Protein-Protein Interaction Changes in an Archaeal Light-Signal Transduction
por: Kandori, Hideki, et al.
Publicado: (2010)

Glycosphingolipid–Protein Interaction in Signal Transduction
por: Russo, Domenico, et al.
Publicado: (2016)

Polymeric Microspheres as Protein Transduction Reagents
por: Nagel, David, et al.
Publicado: (2014)

Restoring functional neurofibromin by protein transduction
por: Mellert, K., et al.
Publicado: (2018)

Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of Streptomyces coelicolor A3(2)
por: Ferdous, Nadim, et al.
Publicado: (2020)

Reconstituted cell-free protein synthesis using in vitro transcribed tRNAs
por: Hibi, Keita, et al.
Publicado: (2020)

Evaluation of antibody responses to the early transcribed membrane protein family in Plasmodium vivax
por: Lee, Seong-Kyun, et al.
Publicado: (2019)

A Sco protein among the hypothetical proteins of Bacillus lehensis G1: Its 3D macromolecular structure and association with Cytochrome C Oxidase
por: Tan, Soo Huei, et al.
Publicado: (2014)

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction
por: Gump, Jacob M., et al.
Publicado: (2010)

Effect of Boar Sperm Proteins and Quality Changes on Field Fertility
por: Michos, Ilias, et al.
Publicado: (2021)

Heat-shock proteins and mRNAs in liver and hepatoma.
por: Bardella, L., et al.
Publicado: (1987)

Driving DNA transposition by lentiviral protein transduction
por: Cai, Yujia, et al.
Publicado: (2014)

Low protein feeding and energy transduction in rats
por: Maloney, Shane K
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c5fggfsm46p7hq923ah7rh7ieo