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Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer

The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents...

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Autores principales: Yoon, Ji Hye, Kim, Mi-Yeon, Cho, Jae Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861958/
https://www.ncbi.nlm.nih.gov/pubmed/36675015
http://dx.doi.org/10.3390/ijms24021498
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author Yoon, Ji Hye
Kim, Mi-Yeon
Cho, Jae Youl
author_facet Yoon, Ji Hye
Kim, Mi-Yeon
Cho, Jae Youl
author_sort Yoon, Ji Hye
collection PubMed
description The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents causes severe skin diseases, including atopic dermatitis, pruritus, psoriasis, skin cancer, and vitiligo. Members of the flavonoid family include apigenin, quercetin, luteolin, and kaempferol. Of these, apigenin has been used as a dietary supplement due to its various biological activities and has been shown to reduce skin inflammation by downregulating various inflammatory markers and molecular targets. In this review, we deal with current knowledge about inflammatory reactions in the skin and the molecular mechanisms by which apigenin reduces skin inflammation.
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spelling pubmed-98619582023-01-22 Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer Yoon, Ji Hye Kim, Mi-Yeon Cho, Jae Youl Int J Mol Sci Review The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents causes severe skin diseases, including atopic dermatitis, pruritus, psoriasis, skin cancer, and vitiligo. Members of the flavonoid family include apigenin, quercetin, luteolin, and kaempferol. Of these, apigenin has been used as a dietary supplement due to its various biological activities and has been shown to reduce skin inflammation by downregulating various inflammatory markers and molecular targets. In this review, we deal with current knowledge about inflammatory reactions in the skin and the molecular mechanisms by which apigenin reduces skin inflammation. MDPI 2023-01-12 /pmc/articles/PMC9861958/ /pubmed/36675015 http://dx.doi.org/10.3390/ijms24021498 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yoon, Ji Hye
Kim, Mi-Yeon
Cho, Jae Youl
Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
title Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
title_full Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
title_fullStr Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
title_full_unstemmed Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
title_short Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
title_sort apigenin: a therapeutic agent for treatment of skin inflammatory diseases and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861958/
https://www.ncbi.nlm.nih.gov/pubmed/36675015
http://dx.doi.org/10.3390/ijms24021498
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