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Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer
The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861958/ https://www.ncbi.nlm.nih.gov/pubmed/36675015 http://dx.doi.org/10.3390/ijms24021498 |
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author | Yoon, Ji Hye Kim, Mi-Yeon Cho, Jae Youl |
author_facet | Yoon, Ji Hye Kim, Mi-Yeon Cho, Jae Youl |
author_sort | Yoon, Ji Hye |
collection | PubMed |
description | The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents causes severe skin diseases, including atopic dermatitis, pruritus, psoriasis, skin cancer, and vitiligo. Members of the flavonoid family include apigenin, quercetin, luteolin, and kaempferol. Of these, apigenin has been used as a dietary supplement due to its various biological activities and has been shown to reduce skin inflammation by downregulating various inflammatory markers and molecular targets. In this review, we deal with current knowledge about inflammatory reactions in the skin and the molecular mechanisms by which apigenin reduces skin inflammation. |
format | Online Article Text |
id | pubmed-9861958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98619582023-01-22 Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer Yoon, Ji Hye Kim, Mi-Yeon Cho, Jae Youl Int J Mol Sci Review The skin is the main barrier between the body and the environment, protecting it from external oxidative stress induced by ultraviolet rays. It also prevents the entrance of infectious agents such as viruses, external antigens, allergens, and bacteria into our bodies. An overreaction to these agents causes severe skin diseases, including atopic dermatitis, pruritus, psoriasis, skin cancer, and vitiligo. Members of the flavonoid family include apigenin, quercetin, luteolin, and kaempferol. Of these, apigenin has been used as a dietary supplement due to its various biological activities and has been shown to reduce skin inflammation by downregulating various inflammatory markers and molecular targets. In this review, we deal with current knowledge about inflammatory reactions in the skin and the molecular mechanisms by which apigenin reduces skin inflammation. MDPI 2023-01-12 /pmc/articles/PMC9861958/ /pubmed/36675015 http://dx.doi.org/10.3390/ijms24021498 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yoon, Ji Hye Kim, Mi-Yeon Cho, Jae Youl Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer |
title | Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer |
title_full | Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer |
title_fullStr | Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer |
title_full_unstemmed | Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer |
title_short | Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer |
title_sort | apigenin: a therapeutic agent for treatment of skin inflammatory diseases and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861958/ https://www.ncbi.nlm.nih.gov/pubmed/36675015 http://dx.doi.org/10.3390/ijms24021498 |
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