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Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment

Polydopamine (PDA) is a natural melanin derived from marine mussels that has good biocompatibility, biodegradability, and photothermal conversion ability. As a new coating material, it offers a novel way to modify the surface of various substances. The drug loading capacity and encapsulation efficie...

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Autores principales: Ma, Hualin, Peng, Jingwen, Zhang, Jianing, Pan, Li, Ouyang, Jiayi, Li, Zimu, Guo, Baochun, Wang, Zhen, Xu, Ying, Lian, Daizheng, Zeng, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861962/
https://www.ncbi.nlm.nih.gov/pubmed/36678644
http://dx.doi.org/10.3390/pharmaceutics15010015
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author Ma, Hualin
Peng, Jingwen
Zhang, Jianing
Pan, Li
Ouyang, Jiayi
Li, Zimu
Guo, Baochun
Wang, Zhen
Xu, Ying
Lian, Daizheng
Zeng, Xiaowei
author_facet Ma, Hualin
Peng, Jingwen
Zhang, Jianing
Pan, Li
Ouyang, Jiayi
Li, Zimu
Guo, Baochun
Wang, Zhen
Xu, Ying
Lian, Daizheng
Zeng, Xiaowei
author_sort Ma, Hualin
collection PubMed
description Polydopamine (PDA) is a natural melanin derived from marine mussels that has good biocompatibility, biodegradability, and photothermal conversion ability. As a new coating material, it offers a novel way to modify the surface of various substances. The drug loading capacity and encapsulation efficiency of PDA are greatly improved via the use of mesoporous materials. The abundant pore canals on mesoporous polydopamine (MPDA) exhibit a uniquely large surface area, which provides a structural basis for drug delivery. In this review, we systematically summarized the characteristics and manufacturing process of MPDA, introduced its application in the diagnosis and treatment of cancer, and discussed the existing problems in its development and clinical application. This comprehensive review will facilitate further research on MPDA in the fields of medicine including cancer therapy, materials science, and biology.
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spelling pubmed-98619622023-01-22 Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment Ma, Hualin Peng, Jingwen Zhang, Jianing Pan, Li Ouyang, Jiayi Li, Zimu Guo, Baochun Wang, Zhen Xu, Ying Lian, Daizheng Zeng, Xiaowei Pharmaceutics Review Polydopamine (PDA) is a natural melanin derived from marine mussels that has good biocompatibility, biodegradability, and photothermal conversion ability. As a new coating material, it offers a novel way to modify the surface of various substances. The drug loading capacity and encapsulation efficiency of PDA are greatly improved via the use of mesoporous materials. The abundant pore canals on mesoporous polydopamine (MPDA) exhibit a uniquely large surface area, which provides a structural basis for drug delivery. In this review, we systematically summarized the characteristics and manufacturing process of MPDA, introduced its application in the diagnosis and treatment of cancer, and discussed the existing problems in its development and clinical application. This comprehensive review will facilitate further research on MPDA in the fields of medicine including cancer therapy, materials science, and biology. MDPI 2022-12-21 /pmc/articles/PMC9861962/ /pubmed/36678644 http://dx.doi.org/10.3390/pharmaceutics15010015 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Hualin
Peng, Jingwen
Zhang, Jianing
Pan, Li
Ouyang, Jiayi
Li, Zimu
Guo, Baochun
Wang, Zhen
Xu, Ying
Lian, Daizheng
Zeng, Xiaowei
Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
title Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
title_full Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
title_fullStr Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
title_full_unstemmed Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
title_short Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
title_sort frontiers in preparations and promising applications of mesoporous polydopamine for cancer diagnosis and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861962/
https://www.ncbi.nlm.nih.gov/pubmed/36678644
http://dx.doi.org/10.3390/pharmaceutics15010015
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