A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase

Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activit...

Descripción completa

Detalles Bibliográficos
Autores principales: Oliveira, Isadora, Costa, Victor, Veras, Flávio, Ferreira, Isabela, Cunha, Fernando, Cunha, Thiago, Monteiro, Wuelton, Arantes, Eliane, Pucca, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861997/
https://www.ncbi.nlm.nih.gov/pubmed/36668864
http://dx.doi.org/10.3390/toxins15010044
_version_ 1784874981982732288
author Oliveira, Isadora
Costa, Victor
Veras, Flávio
Ferreira, Isabela
Cunha, Fernando
Cunha, Thiago
Monteiro, Wuelton
Arantes, Eliane
Pucca, Manuela
author_facet Oliveira, Isadora
Costa, Victor
Veras, Flávio
Ferreira, Isabela
Cunha, Fernando
Cunha, Thiago
Monteiro, Wuelton
Arantes, Eliane
Pucca, Manuela
author_sort Oliveira, Isadora
collection PubMed
description Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the CdcPDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report a new finding about CdcPDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases.
format Online
Article
Text
id pubmed-9861997
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98619972023-01-22 A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase Oliveira, Isadora Costa, Victor Veras, Flávio Ferreira, Isabela Cunha, Fernando Cunha, Thiago Monteiro, Wuelton Arantes, Eliane Pucca, Manuela Toxins (Basel) Communication Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the CdcPDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report a new finding about CdcPDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases. MDPI 2023-01-05 /pmc/articles/PMC9861997/ /pubmed/36668864 http://dx.doi.org/10.3390/toxins15010044 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Oliveira, Isadora
Costa, Victor
Veras, Flávio
Ferreira, Isabela
Cunha, Fernando
Cunha, Thiago
Monteiro, Wuelton
Arantes, Eliane
Pucca, Manuela
A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase
title A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase
title_full A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase
title_fullStr A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase
title_full_unstemmed A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase
title_short A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: CdcPDE, a Rattlesnake Phosphodiesterase
title_sort promising biomolecule able to degrade neutrophil extracellular traps: cdcpde, a rattlesnake phosphodiesterase
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861997/
https://www.ncbi.nlm.nih.gov/pubmed/36668864
http://dx.doi.org/10.3390/toxins15010044
work_keys_str_mv AT oliveiraisadora apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT costavictor apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT verasflavio apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT ferreiraisabela apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT cunhafernando apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT cunhathiago apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT monteirowuelton apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT aranteseliane apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT puccamanuela apromisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT oliveiraisadora promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT costavictor promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT verasflavio promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT ferreiraisabela promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT cunhafernando promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT cunhathiago promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT monteirowuelton promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT aranteseliane promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase
AT puccamanuela promisingbiomoleculeabletodegradeneutrophilextracellulartrapscdcpdearattlesnakephosphodiesterase

Ejemplares similares