A Synthetic Polymicrobial Community Biofilm Model Demonstrates Spatial Partitioning, Tolerance to Antimicrobial Treatment, Reduced Metabolism, and Small Colony Variants Typical of Chronic Wound Biofilms

Understanding chronic wound infection is key for successful treatment and requires accurate laboratory models. We describe a modified biofilm flow device that effectively mimics the chronic wound environment, including simulated wound fluid, a collagen-based 3D biofilm matrix, and a five-species mix...

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Detalles Bibliográficos
Autores principales: Khalid, Ammara, Cookson, Alan R., Whitworth, David E., Beeton, Michael L., Robins, Lori I., Maddocks, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862141/
https://www.ncbi.nlm.nih.gov/pubmed/36678466
http://dx.doi.org/10.3390/pathogens12010118

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