Cargando…

Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats

Peptic ulcer is a widespread disease, with a lifetime frequency of 5–10% among the general population and an annual incidence of 0.1–0.3%. Ovothiol A is naturally produced from sea urchin eggs with special antioxidant activity. Gastric ulcers were induced in rats by a single ethanol dose (5 mL/kg)....

Descripción completa

Detalles Bibliográficos
Autores principales: Salaheldin, Amira Tarek, Shehata, Mohamed Refaat, Sakr, Hader I., Atia, Tarek, Mohamed, Ayman Saber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862145/
https://www.ncbi.nlm.nih.gov/pubmed/36662198
http://dx.doi.org/10.3390/md21010025
_version_ 1784875020197036032
author Salaheldin, Amira Tarek
Shehata, Mohamed Refaat
Sakr, Hader I.
Atia, Tarek
Mohamed, Ayman Saber
author_facet Salaheldin, Amira Tarek
Shehata, Mohamed Refaat
Sakr, Hader I.
Atia, Tarek
Mohamed, Ayman Saber
author_sort Salaheldin, Amira Tarek
collection PubMed
description Peptic ulcer is a widespread disease, with a lifetime frequency of 5–10% among the general population and an annual incidence of 0.1–0.3%. Ovothiol A is naturally produced from sea urchin eggs with special antioxidant activity. Gastric ulcers were induced in rats by a single ethanol dose (5 mL/kg). The rats were divided into control, ulcer, and ulcer with 250 and 500 mg/kg ovothiol A doses. Molecular docking studies were used to examine the interactions between ovothiol A and the H+/K+ ATPase active site residues. Ovothiol A led to a significant decline (p < 0.05) in gastric juice volume, ulcer index, MDA, IL-6, and cytochrome c, while levels of gastric juice pH, GSH, CAT, GST, SOD, and NO increased. Histopathological investigation of stomach sections revealed architecture preservation of the gastric mucosa after ovothiol A administration. The anti-ulcerogenic activity of ovothiol A includes scavenging free radicals, inhibition of inflammation, regulation of apoptosis, and stabilization of fibroblast growth factors to promote gastric ulcers healing.
format Online
Article
Text
id pubmed-9862145
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98621452023-01-22 Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats Salaheldin, Amira Tarek Shehata, Mohamed Refaat Sakr, Hader I. Atia, Tarek Mohamed, Ayman Saber Mar Drugs Article Peptic ulcer is a widespread disease, with a lifetime frequency of 5–10% among the general population and an annual incidence of 0.1–0.3%. Ovothiol A is naturally produced from sea urchin eggs with special antioxidant activity. Gastric ulcers were induced in rats by a single ethanol dose (5 mL/kg). The rats were divided into control, ulcer, and ulcer with 250 and 500 mg/kg ovothiol A doses. Molecular docking studies were used to examine the interactions between ovothiol A and the H+/K+ ATPase active site residues. Ovothiol A led to a significant decline (p < 0.05) in gastric juice volume, ulcer index, MDA, IL-6, and cytochrome c, while levels of gastric juice pH, GSH, CAT, GST, SOD, and NO increased. Histopathological investigation of stomach sections revealed architecture preservation of the gastric mucosa after ovothiol A administration. The anti-ulcerogenic activity of ovothiol A includes scavenging free radicals, inhibition of inflammation, regulation of apoptosis, and stabilization of fibroblast growth factors to promote gastric ulcers healing. MDPI 2022-12-28 /pmc/articles/PMC9862145/ /pubmed/36662198 http://dx.doi.org/10.3390/md21010025 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salaheldin, Amira Tarek
Shehata, Mohamed Refaat
Sakr, Hader I.
Atia, Tarek
Mohamed, Ayman Saber
Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats
title Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats
title_full Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats
title_fullStr Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats
title_full_unstemmed Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats
title_short Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats
title_sort therapeutic potency of ovothiol a on ethanol-induced gastric ulcers in wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862145/
https://www.ncbi.nlm.nih.gov/pubmed/36662198
http://dx.doi.org/10.3390/md21010025
work_keys_str_mv AT salaheldinamiratarek therapeuticpotencyofovothiolaonethanolinducedgastriculcersinwistarrats
AT shehatamohamedrefaat therapeuticpotencyofovothiolaonethanolinducedgastriculcersinwistarrats
AT sakrhaderi therapeuticpotencyofovothiolaonethanolinducedgastriculcersinwistarrats
AT atiatarek therapeuticpotencyofovothiolaonethanolinducedgastriculcersinwistarrats
AT mohamedaymansaber therapeuticpotencyofovothiolaonethanolinducedgastriculcersinwistarrats