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Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862157/ https://www.ncbi.nlm.nih.gov/pubmed/36668915 http://dx.doi.org/10.3390/tropicalmed8010008 |
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author | Teague, Destini Gurnari, Carmelo Awada, Hussein Maciejewski, Jaroslaw P. Ibrahim, Ibrahim Bat, Taha |
author_facet | Teague, Destini Gurnari, Carmelo Awada, Hussein Maciejewski, Jaroslaw P. Ibrahim, Ibrahim Bat, Taha |
author_sort | Teague, Destini |
collection | PubMed |
description | Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated mechanisms. Besides being merely speculative and considering the rarity of the disorder, the description of acquired pure red cell aplasia clinical associations represents a unique occasion to improve our current clinical knowledge of the disease, reveal clues on its pathogenesis, and guide therapeutic decisions. The varied clinical scenarios and common acquired pure red cell aplasia associated conditions (i.e., thymoma, T cell/NK-cell large granular lymphocyte leukemia, B cell dyscrasia) suggest a heterogeneity of pathogenic routes. Viral etiologies must always be considered and worked up in the initial assessment of newly diagnosed acquired pure red cell aplasia patients. In this report, we present two cases of hepatitis-C-related acquired pure red cell aplasia and successful use of anti-viral strategies in the achievement of a complete response. |
format | Online Article Text |
id | pubmed-9862157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98621572023-01-22 Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia Teague, Destini Gurnari, Carmelo Awada, Hussein Maciejewski, Jaroslaw P. Ibrahim, Ibrahim Bat, Taha Trop Med Infect Dis Case Report Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated mechanisms. Besides being merely speculative and considering the rarity of the disorder, the description of acquired pure red cell aplasia clinical associations represents a unique occasion to improve our current clinical knowledge of the disease, reveal clues on its pathogenesis, and guide therapeutic decisions. The varied clinical scenarios and common acquired pure red cell aplasia associated conditions (i.e., thymoma, T cell/NK-cell large granular lymphocyte leukemia, B cell dyscrasia) suggest a heterogeneity of pathogenic routes. Viral etiologies must always be considered and worked up in the initial assessment of newly diagnosed acquired pure red cell aplasia patients. In this report, we present two cases of hepatitis-C-related acquired pure red cell aplasia and successful use of anti-viral strategies in the achievement of a complete response. MDPI 2022-12-22 /pmc/articles/PMC9862157/ /pubmed/36668915 http://dx.doi.org/10.3390/tropicalmed8010008 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Teague, Destini Gurnari, Carmelo Awada, Hussein Maciejewski, Jaroslaw P. Ibrahim, Ibrahim Bat, Taha Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia |
title | Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia |
title_full | Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia |
title_fullStr | Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia |
title_full_unstemmed | Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia |
title_short | Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia |
title_sort | hepatitis c infection associated with acquired pure red cell aplasia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862157/ https://www.ncbi.nlm.nih.gov/pubmed/36668915 http://dx.doi.org/10.3390/tropicalmed8010008 |
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