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Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia

Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated m...

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Autores principales: Teague, Destini, Gurnari, Carmelo, Awada, Hussein, Maciejewski, Jaroslaw P., Ibrahim, Ibrahim, Bat, Taha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862157/
https://www.ncbi.nlm.nih.gov/pubmed/36668915
http://dx.doi.org/10.3390/tropicalmed8010008
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author Teague, Destini
Gurnari, Carmelo
Awada, Hussein
Maciejewski, Jaroslaw P.
Ibrahim, Ibrahim
Bat, Taha
author_facet Teague, Destini
Gurnari, Carmelo
Awada, Hussein
Maciejewski, Jaroslaw P.
Ibrahim, Ibrahim
Bat, Taha
author_sort Teague, Destini
collection PubMed
description Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated mechanisms. Besides being merely speculative and considering the rarity of the disorder, the description of acquired pure red cell aplasia clinical associations represents a unique occasion to improve our current clinical knowledge of the disease, reveal clues on its pathogenesis, and guide therapeutic decisions. The varied clinical scenarios and common acquired pure red cell aplasia associated conditions (i.e., thymoma, T cell/NK-cell large granular lymphocyte leukemia, B cell dyscrasia) suggest a heterogeneity of pathogenic routes. Viral etiologies must always be considered and worked up in the initial assessment of newly diagnosed acquired pure red cell aplasia patients. In this report, we present two cases of hepatitis-C-related acquired pure red cell aplasia and successful use of anti-viral strategies in the achievement of a complete response.
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spelling pubmed-98621572023-01-22 Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia Teague, Destini Gurnari, Carmelo Awada, Hussein Maciejewski, Jaroslaw P. Ibrahim, Ibrahim Bat, Taha Trop Med Infect Dis Case Report Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated mechanisms. Besides being merely speculative and considering the rarity of the disorder, the description of acquired pure red cell aplasia clinical associations represents a unique occasion to improve our current clinical knowledge of the disease, reveal clues on its pathogenesis, and guide therapeutic decisions. The varied clinical scenarios and common acquired pure red cell aplasia associated conditions (i.e., thymoma, T cell/NK-cell large granular lymphocyte leukemia, B cell dyscrasia) suggest a heterogeneity of pathogenic routes. Viral etiologies must always be considered and worked up in the initial assessment of newly diagnosed acquired pure red cell aplasia patients. In this report, we present two cases of hepatitis-C-related acquired pure red cell aplasia and successful use of anti-viral strategies in the achievement of a complete response. MDPI 2022-12-22 /pmc/articles/PMC9862157/ /pubmed/36668915 http://dx.doi.org/10.3390/tropicalmed8010008 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Teague, Destini
Gurnari, Carmelo
Awada, Hussein
Maciejewski, Jaroslaw P.
Ibrahim, Ibrahim
Bat, Taha
Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
title Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
title_full Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
title_fullStr Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
title_full_unstemmed Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
title_short Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia
title_sort hepatitis c infection associated with acquired pure red cell aplasia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862157/
https://www.ncbi.nlm.nih.gov/pubmed/36668915
http://dx.doi.org/10.3390/tropicalmed8010008
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