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Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder?
Accumulated evidence has demonstrated abnormal amygdala activation in bipolar disorder (BD). The olfactory bulb (OB) has vigorous connections with the amygdala. Although odor-related functions of the OB decreased during the evolutionary process, we hypothesized that an evolved OB with increased acti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862245/ https://www.ncbi.nlm.nih.gov/pubmed/36680695 http://dx.doi.org/10.1007/s00702-023-02587-9 |
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author | Sancaktar, Muhammet Kocamer Şahin, Şengül Demir, Bahadır Elboğa, Umut Elboğa, Gülçin Altındağ, Abdurrahman |
author_facet | Sancaktar, Muhammet Kocamer Şahin, Şengül Demir, Bahadır Elboğa, Umut Elboğa, Gülçin Altındağ, Abdurrahman |
author_sort | Sancaktar, Muhammet |
collection | PubMed |
description | Accumulated evidence has demonstrated abnormal amygdala activation in bipolar disorder (BD). The olfactory bulb (OB) has vigorous connections with the amygdala. Although odor-related functions of the OB decreased during the evolutionary process, we hypothesized that an evolved OB with increased activation in emotion regulation may be one of the main factors affecting amygdala functions in BD. Our aim was to investigate metabolism in the OB and amygdala in patients with BD. Twenty-six patients diagnosed with BD according to DSM-5 diagnostic criteria were included in this cross-sectional study. Metabolism in the OB and amygdala was assessed using fluorodeoxyglucose positron emission tomography/CT in patients with BD. The OB and amygdala metabolism was compared with the patients’ Z scores. Both OB and amygdala metabolic activities were significantly higher than in the controls. A positive correlation was detected between right/left amygdala metabolism and right OB metabolism (p < 0.05, r:467 and r:662, respectively). This study increased our understanding of the etiopathogenesis of BD. In BD, the main cause of hypermetabolism in the amygdala may be increased metabolism in the OB. During evolution, the OB may have assumed a dominant role in emotional processing rather than olfactory functions. |
format | Online Article Text |
id | pubmed-9862245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-98622452023-01-23 Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? Sancaktar, Muhammet Kocamer Şahin, Şengül Demir, Bahadır Elboğa, Umut Elboğa, Gülçin Altındağ, Abdurrahman J Neural Transm (Vienna) Psychiatry and Preclinical Psychiatric Studies - Original Article Accumulated evidence has demonstrated abnormal amygdala activation in bipolar disorder (BD). The olfactory bulb (OB) has vigorous connections with the amygdala. Although odor-related functions of the OB decreased during the evolutionary process, we hypothesized that an evolved OB with increased activation in emotion regulation may be one of the main factors affecting amygdala functions in BD. Our aim was to investigate metabolism in the OB and amygdala in patients with BD. Twenty-six patients diagnosed with BD according to DSM-5 diagnostic criteria were included in this cross-sectional study. Metabolism in the OB and amygdala was assessed using fluorodeoxyglucose positron emission tomography/CT in patients with BD. The OB and amygdala metabolism was compared with the patients’ Z scores. Both OB and amygdala metabolic activities were significantly higher than in the controls. A positive correlation was detected between right/left amygdala metabolism and right OB metabolism (p < 0.05, r:467 and r:662, respectively). This study increased our understanding of the etiopathogenesis of BD. In BD, the main cause of hypermetabolism in the amygdala may be increased metabolism in the OB. During evolution, the OB may have assumed a dominant role in emotional processing rather than olfactory functions. Springer Vienna 2023-01-21 2023 /pmc/articles/PMC9862245/ /pubmed/36680695 http://dx.doi.org/10.1007/s00702-023-02587-9 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Psychiatry and Preclinical Psychiatric Studies - Original Article Sancaktar, Muhammet Kocamer Şahin, Şengül Demir, Bahadır Elboğa, Umut Elboğa, Gülçin Altındağ, Abdurrahman Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
title | Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
title_full | Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
title_fullStr | Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
title_full_unstemmed | Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
title_short | Is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
title_sort | is abnormal metabolism in the olfactory bulb and amygdala associated with bipolar disorder? |
topic | Psychiatry and Preclinical Psychiatric Studies - Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862245/ https://www.ncbi.nlm.nih.gov/pubmed/36680695 http://dx.doi.org/10.1007/s00702-023-02587-9 |
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