Cargando…

Systematic comparison of transcriptomes of Caco-2 cells cultured under different cellular and physiological conditions

There is a need for standardized in vitro models emulating the functionalities of the human intestinal tract to study human intestinal health without the use of laboratory animals. The Caco-2 cell line is a well-accepted and highly characterized intestinal barrier model, which has been intensively u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elzinga, Janneke, Grouls, Menno, Hooiveld, Guido J. E. J., van der Zande, Meike, Smidt, Hauke, Bouwmeester, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	In Vitro Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862247/ https://www.ncbi.nlm.nih.gov/pubmed/36680592 http://dx.doi.org/10.1007/s00204-022-03430-y

Ejemplares similares

Differential gene expression in iPSC-derived human intestinal epithelial cell layers following exposure to two concentrations of butyrate, propionate and acetate
por: Grouls, Menno, et al.
Publicado: (2022)

Effects of bisphenol F, bisphenol S, and bisphenol AF on cultured human osteoblasts
por: García-Recio, E., et al.
Publicado: (2023)

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
por: Delp, Johannes, et al.
Publicado: (2021)

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis
por: Smirnova, L., et al.
Publicado: (2015)

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
por: van der Stel, Wanda, et al.
Publicado: (2021)

Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity
por: Reffatto, V., et al.
Publicado: (2017)

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration
por: Pallocca, Giorgia, et al.
Publicado: (2015)

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors
por: Rempel, Eugen, et al.
Publicado: (2015)

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift
por: Gutbier, Simon, et al.
Publicado: (2018)

Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models
por: Capinha, Liliana, et al.
Publicado: (2022)

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests
por: Shinde, Vaibhav, et al.
Publicado: (2016)

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery
por: Zimmer, B., et al.
Publicado: (2014)

Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells
por: Lucendo-Villarin, Baltasar, et al.
Publicado: (2017)

Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia
por: Kulthong, Kornphimol, et al.
Publicado: (2021)

Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis
por: Karsten, R. E. H., et al.
Publicado: (2022)

Extending the viability of human precision-cut intestinal slice model for drug metabolism studies
por: Biel, C., et al.
Publicado: (2022)

The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment
por: Callegaro, Giulia, et al.
Publicado: (2021)

Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line
por: Malinowska, Julia M., et al.
Publicado: (2023)

Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics
por: Kasteel, Emma E. J., et al.
Publicado: (2020)

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds
por: Karhu, S. Tuuli, et al.
Publicado: (2018)

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
por: Proctor, William R., et al.
Publicado: (2017)

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone
por: Harris, Georgina, et al.
Publicado: (2018)

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
por: Rashidi, Hassan, et al.
Publicado: (2018)

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
por: Copple, Ian M., et al.
Publicado: (2018)

Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
por: Snijders, Kirsten E., et al.
Publicado: (2021)

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles
por: Hoelting, Lisa, et al.
Publicado: (2012)

Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods
por: Adriaens, Els, et al.
Publicado: (2013)

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
por: Colaianna, Marilena, et al.
Publicado: (2016)

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants
por: Hirsch, Cordula, et al.
Publicado: (2016)

Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium
por: Fischer, Bettina Maria, et al.
Publicado: (2015)

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue
por: Godoy, Patricio, et al.
Publicado: (2016)

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
por: Chaudhari, Umesh, et al.
Publicado: (2015)

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
por: Nemade, Harshal, et al.
Publicado: (2018)

Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis
por: Piao, Mei Jing, et al.
Publicado: (2018)

Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence
por: Lee, Jia-Ying Joey, et al.
Publicado: (2018)

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury
por: Wink, Steven, et al.
Publicado: (2018)

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen
por: Windt, Tímea, et al.
Publicado: (2019)

Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
por: Thiel, Christoph, et al.
Publicado: (2016)

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities
por: Wink, Steven, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_epo41uadp4eo4abnmn59pdiqtl