Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions

Chinese hamster ovary (CHO) cell lines are widely used to manufacture biopharmaceuticals. However, CHO cells are not an optimal expression host due to the intrinsic plasticity of the CHO genome. Genome plasticity can lead to chromosomal rearrangements, transgene exclusion, and phenotypic drift. A po...

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Detalles Bibliográficos
Autores principales: Chitwood, Dylan G., Wang, Qinghua, Klaubert, Stephanie R., Green, Kiana, Wu, Cathy H., Harcum, Sarah W., Saski, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862248/
https://www.ncbi.nlm.nih.gov/pubmed/36681715
http://dx.doi.org/10.1038/s41598-023-27962-0

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