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Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer

Purpose: To evaluate the clinical utility of serum luteinizing hormone (LH) level in predicting frozen embryo transfer (FET) outcomes among the patients with an ovulation induction (OI) cycle. Methods: A total of 250 patients who underwent OI cycle frozen–thawed embryo transfer from January 2018 to...

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Autores principales: Shi, Qingqing, Jiang, Yue, Kong, Na, Huang, Chenyang, Liu, Jingyu, Shen, Xiaoyue, Sun, Yanxin, Lu, Feifei, Mei, Jie, Zhou, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862278/
https://www.ncbi.nlm.nih.gov/pubmed/36675713
http://dx.doi.org/10.3390/jpm13010052
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author Shi, Qingqing
Jiang, Yue
Kong, Na
Huang, Chenyang
Liu, Jingyu
Shen, Xiaoyue
Sun, Yanxin
Lu, Feifei
Mei, Jie
Zhou, Jianjun
author_facet Shi, Qingqing
Jiang, Yue
Kong, Na
Huang, Chenyang
Liu, Jingyu
Shen, Xiaoyue
Sun, Yanxin
Lu, Feifei
Mei, Jie
Zhou, Jianjun
author_sort Shi, Qingqing
collection PubMed
description Purpose: To evaluate the clinical utility of serum luteinizing hormone (LH) level in predicting frozen embryo transfer (FET) outcomes among the patients with an ovulation induction (OI) cycle. Methods: A total of 250 patients who underwent OI cycle frozen–thawed embryo transfer from January 2018 to June 2020 in Drum Tower Hospital affiliated with Nanjing University Medical School were retrospectively analyzed. The primary outcomes were clinical pregnancy rate and the live birth rate. Results: The results showed that a significant difference in Serum LH level on the day of human chorionic gonadotropin (hCG) administration was observed between the clinical pregnancy group and no clinical pregnancy group (p = 0.002), while there was no significant difference between the live birth group and no live birth group (p = 0.06). Multiple logistic regression analysis of factors related to clinical pregnancy showed serum LH level on the day of hCG administration was related to improved clinical pregnancy rate (OR was 1.02, 95% CI: 1.0–1.03, p = 0.02), while serum LH level had no significant effect on live birth rate. The ROC curves revealed the serum LH level was significantly correlated with clinical pregnancy rate and live birth rate; the cut-off point of serum LH level on the day of hCG administration was 8.46 miu/mL for clinical pregnancy rate (AUC 0.609, p = 0.003). Conclusion: In patients with OI FET, serum LH level on the day of hCG administration might be a biomarker for the prediction of clinical pregnancy. The prediction that patients who underwent OI cycle frozen–thawed embryo transfer with serum LH levels below 8.46 mIU /mL might be pregnant appeared to be meaningful.
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spelling pubmed-98622782023-01-22 Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer Shi, Qingqing Jiang, Yue Kong, Na Huang, Chenyang Liu, Jingyu Shen, Xiaoyue Sun, Yanxin Lu, Feifei Mei, Jie Zhou, Jianjun J Pers Med Article Purpose: To evaluate the clinical utility of serum luteinizing hormone (LH) level in predicting frozen embryo transfer (FET) outcomes among the patients with an ovulation induction (OI) cycle. Methods: A total of 250 patients who underwent OI cycle frozen–thawed embryo transfer from January 2018 to June 2020 in Drum Tower Hospital affiliated with Nanjing University Medical School were retrospectively analyzed. The primary outcomes were clinical pregnancy rate and the live birth rate. Results: The results showed that a significant difference in Serum LH level on the day of human chorionic gonadotropin (hCG) administration was observed between the clinical pregnancy group and no clinical pregnancy group (p = 0.002), while there was no significant difference between the live birth group and no live birth group (p = 0.06). Multiple logistic regression analysis of factors related to clinical pregnancy showed serum LH level on the day of hCG administration was related to improved clinical pregnancy rate (OR was 1.02, 95% CI: 1.0–1.03, p = 0.02), while serum LH level had no significant effect on live birth rate. The ROC curves revealed the serum LH level was significantly correlated with clinical pregnancy rate and live birth rate; the cut-off point of serum LH level on the day of hCG administration was 8.46 miu/mL for clinical pregnancy rate (AUC 0.609, p = 0.003). Conclusion: In patients with OI FET, serum LH level on the day of hCG administration might be a biomarker for the prediction of clinical pregnancy. The prediction that patients who underwent OI cycle frozen–thawed embryo transfer with serum LH levels below 8.46 mIU /mL might be pregnant appeared to be meaningful. MDPI 2022-12-27 /pmc/articles/PMC9862278/ /pubmed/36675713 http://dx.doi.org/10.3390/jpm13010052 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Qingqing
Jiang, Yue
Kong, Na
Huang, Chenyang
Liu, Jingyu
Shen, Xiaoyue
Sun, Yanxin
Lu, Feifei
Mei, Jie
Zhou, Jianjun
Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer
title Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer
title_full Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer
title_fullStr Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer
title_full_unstemmed Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer
title_short Serum LH Level on the Day of hCG Administration as a Predictor of the Reproductive Outcomes in Ovulation Induction Cycle Frozen–Thawed Embryo Transfer
title_sort serum lh level on the day of hcg administration as a predictor of the reproductive outcomes in ovulation induction cycle frozen–thawed embryo transfer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862278/
https://www.ncbi.nlm.nih.gov/pubmed/36675713
http://dx.doi.org/10.3390/jpm13010052
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