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LC-MS Analysis and Antifungal Activity of Turnera subulata Sm.

Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it di...

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Detalles Bibliográficos
Autores principales: Andrade-Pinheiro, Jacqueline Cosmo, Sobral de Souza, Celestina Elba, Ribeiro, Daiany Alves, Silva, Andressa de Alencar, da Silva, Viviane Bezerra, dos Santos, Antonia Thassya Lucas, Juno Alencar Fonseca, Victor, de Macêdo, Delmacia Gonçalves, da Cruz, Rafael Pereira, Almeida-Bezerra, José Weverton, Machado, Antonio Júdson Targino, de Freitas, Thiago Sampaio, de Brito, Edy Sousa, Ribeiro, Paulo Riceli Vasconcelos, da Costa, José Galberto Martins, Coutinho, Henrique Douglas Melo, Kowalska, Grażyna, Rowiński, Rafał, Kowalski, Radosław, Morais-Braga, Maria Flaviana Bezerra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862381/
https://www.ncbi.nlm.nih.gov/pubmed/36679128
http://dx.doi.org/10.3390/plants12020415
Descripción
Sumario:Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors.