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Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause
Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862461/ https://www.ncbi.nlm.nih.gov/pubmed/36677645 http://dx.doi.org/10.3390/molecules28020587 |
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author | Flores-Aguilar, Luis Ángel Cueto-Escobedo, Jonathan Puga-Olguín, Abraham Olmos-Vázquez, Oscar Jerónimo Rosas-Sánchez, Gilberto Uriel Bernal-Morales, Blandina Rodríguez-Landa, Juan Francisco |
author_facet | Flores-Aguilar, Luis Ángel Cueto-Escobedo, Jonathan Puga-Olguín, Abraham Olmos-Vázquez, Oscar Jerónimo Rosas-Sánchez, Gilberto Uriel Bernal-Morales, Blandina Rodríguez-Landa, Juan Francisco |
author_sort | Flores-Aguilar, Luis Ángel |
collection | PubMed |
description | Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic- and anti-despair-like effects; however, it is unknown whether chrysin exerts a protective effect against the behavioral changes produced by acute stress on locomotor activity and behavioral despair in rats at 12-weeks post-ovariectomy. Ovariectomized female Wistar rats were assigned to eight groups: vehicle group (10% DMSO), three groups with chrysin and three groups with the same dose of allopregnanolone (0.5, 1, and 2 mg/kg), and one group with diazepam (2 mg/kg). The treatments were administered for seven consecutive days and the effects were evaluated in the locomotor activity and swimming tests. Chrysin (2 mg/kg) increased the latency to first immobility and decreased the total immobility time in the swimming test as the reference drugs allopregnanolone and diazepam (2 mg/kg); while locomotor activity prevented the behavioral changes produced by swimming. In conclusion, chrysin exerts a protective effect against the behavioral changes induced by acute stress, similarly to the neurosteroid allopregnanolone and the benzodiazepine diazepam in rats subjected to a surgical menopause model. |
format | Online Article Text |
id | pubmed-9862461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98624612023-01-22 Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause Flores-Aguilar, Luis Ángel Cueto-Escobedo, Jonathan Puga-Olguín, Abraham Olmos-Vázquez, Oscar Jerónimo Rosas-Sánchez, Gilberto Uriel Bernal-Morales, Blandina Rodríguez-Landa, Juan Francisco Molecules Article Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic- and anti-despair-like effects; however, it is unknown whether chrysin exerts a protective effect against the behavioral changes produced by acute stress on locomotor activity and behavioral despair in rats at 12-weeks post-ovariectomy. Ovariectomized female Wistar rats were assigned to eight groups: vehicle group (10% DMSO), three groups with chrysin and three groups with the same dose of allopregnanolone (0.5, 1, and 2 mg/kg), and one group with diazepam (2 mg/kg). The treatments were administered for seven consecutive days and the effects were evaluated in the locomotor activity and swimming tests. Chrysin (2 mg/kg) increased the latency to first immobility and decreased the total immobility time in the swimming test as the reference drugs allopregnanolone and diazepam (2 mg/kg); while locomotor activity prevented the behavioral changes produced by swimming. In conclusion, chrysin exerts a protective effect against the behavioral changes induced by acute stress, similarly to the neurosteroid allopregnanolone and the benzodiazepine diazepam in rats subjected to a surgical menopause model. MDPI 2023-01-06 /pmc/articles/PMC9862461/ /pubmed/36677645 http://dx.doi.org/10.3390/molecules28020587 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Flores-Aguilar, Luis Ángel Cueto-Escobedo, Jonathan Puga-Olguín, Abraham Olmos-Vázquez, Oscar Jerónimo Rosas-Sánchez, Gilberto Uriel Bernal-Morales, Blandina Rodríguez-Landa, Juan Francisco Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
title | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
title_full | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
title_fullStr | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
title_full_unstemmed | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
title_short | Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause |
title_sort | behavioral despair is blocked by the flavonoid chrysin (5,7-dihydroxyflavone) in a rat model of surgical menopause |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862461/ https://www.ncbi.nlm.nih.gov/pubmed/36677645 http://dx.doi.org/10.3390/molecules28020587 |
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