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Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats

Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. Dendropanax morbiferus H.Lév (DM) is a natural product that exh...

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Autores principales: Yang, Ye jin, Song, Jun-Ho, Yang, Ju-Hye, Kim, Min Jung, Kim, Kwang Youn, Kim, Jin-Kyoung, Jin, Yeung Bea, Kim, Woo Hyun, Kim, Suk, Kim, Ki-Rim, Park, Kwang Il, Lee, Hu-Jang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862488/
https://www.ncbi.nlm.nih.gov/pubmed/36677905
http://dx.doi.org/10.3390/molecules28020849
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author Yang, Ye jin
Song, Jun-Ho
Yang, Ju-Hye
Kim, Min Jung
Kim, Kwang Youn
Kim, Jin-Kyoung
Jin, Yeung Bea
Kim, Woo Hyun
Kim, Suk
Kim, Ki-Rim
Park, Kwang Il
Lee, Hu-Jang
author_facet Yang, Ye jin
Song, Jun-Ho
Yang, Ju-Hye
Kim, Min Jung
Kim, Kwang Youn
Kim, Jin-Kyoung
Jin, Yeung Bea
Kim, Woo Hyun
Kim, Suk
Kim, Ki-Rim
Park, Kwang Il
Lee, Hu-Jang
author_sort Yang, Ye jin
collection PubMed
description Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. Dendropanax morbiferus H.Lév (DM) is a natural product that exhibits various biological activities with few side effects. In this study, the potential of DM leaf hot-water extracts (DMWE) as a treatment for periodontitis was determined and its anti-oxidant and anti-inflammatory effects were evaluated. Compounds in DMWE were identified by high-performance liquid chromatography (HPLC) and nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production was measured in RAW 264.7 cells. We measured the gingival index and gingival sulcus depth, and micro-CT was performed in vivo using a ligature-induced periodontitis rat model, which is similar to human periodontitis. The DMWE-treated group exhibited a decrease in cytokine concentration and relieved the gingival index and gingival sulcus depth compared with the periodontitis-induced control group. In addition, micro-CT and histological analysis revealed that DMWE exhibited anti-inflammatory effects and improved alveolar bone loss in periodontitis-induced rats. These findings suggest that DMWE has excellent anti-oxidant and anti-inflammatory effects that protect and prevent periodontal tissue damage and tooth loss caused by the inflammatory response.
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spelling pubmed-98624882023-01-22 Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats Yang, Ye jin Song, Jun-Ho Yang, Ju-Hye Kim, Min Jung Kim, Kwang Youn Kim, Jin-Kyoung Jin, Yeung Bea Kim, Woo Hyun Kim, Suk Kim, Ki-Rim Park, Kwang Il Lee, Hu-Jang Molecules Article Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. Dendropanax morbiferus H.Lév (DM) is a natural product that exhibits various biological activities with few side effects. In this study, the potential of DM leaf hot-water extracts (DMWE) as a treatment for periodontitis was determined and its anti-oxidant and anti-inflammatory effects were evaluated. Compounds in DMWE were identified by high-performance liquid chromatography (HPLC) and nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production was measured in RAW 264.7 cells. We measured the gingival index and gingival sulcus depth, and micro-CT was performed in vivo using a ligature-induced periodontitis rat model, which is similar to human periodontitis. The DMWE-treated group exhibited a decrease in cytokine concentration and relieved the gingival index and gingival sulcus depth compared with the periodontitis-induced control group. In addition, micro-CT and histological analysis revealed that DMWE exhibited anti-inflammatory effects and improved alveolar bone loss in periodontitis-induced rats. These findings suggest that DMWE has excellent anti-oxidant and anti-inflammatory effects that protect and prevent periodontal tissue damage and tooth loss caused by the inflammatory response. MDPI 2023-01-14 /pmc/articles/PMC9862488/ /pubmed/36677905 http://dx.doi.org/10.3390/molecules28020849 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Ye jin
Song, Jun-Ho
Yang, Ju-Hye
Kim, Min Jung
Kim, Kwang Youn
Kim, Jin-Kyoung
Jin, Yeung Bea
Kim, Woo Hyun
Kim, Suk
Kim, Ki-Rim
Park, Kwang Il
Lee, Hu-Jang
Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
title Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
title_full Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
title_fullStr Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
title_full_unstemmed Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
title_short Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
title_sort anti-periodontitis effects of dendropanax morbiferus h.lév leaf extract on ligature-induced periodontitis in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862488/
https://www.ncbi.nlm.nih.gov/pubmed/36677905
http://dx.doi.org/10.3390/molecules28020849
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