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Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis

(1) Background: Arteriovenous fistulas (AVFs) are the preferred access for hemodialysis. Unfortunately, about 60% of patients, especially female patients, fail to receive normal dialysis within one year after surgery because of AVF failure. However, the underlying mechanisms caused by sex difference...

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Autores principales: Hu, Ke, Li, Yiqing, Guo, Yi, Cheng, Peng, Li, Yuxuan, Lu, Chanjun, Cai, Chuanqi, Wang, Weici
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862581/
https://www.ncbi.nlm.nih.gov/pubmed/36661898
http://dx.doi.org/10.3390/jcdd10010003
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author Hu, Ke
Li, Yiqing
Guo, Yi
Cheng, Peng
Li, Yuxuan
Lu, Chanjun
Cai, Chuanqi
Wang, Weici
author_facet Hu, Ke
Li, Yiqing
Guo, Yi
Cheng, Peng
Li, Yuxuan
Lu, Chanjun
Cai, Chuanqi
Wang, Weici
author_sort Hu, Ke
collection PubMed
description (1) Background: Arteriovenous fistulas (AVFs) are the preferred access for hemodialysis. Unfortunately, about 60% of patients, especially female patients, fail to receive normal dialysis within one year after surgery because of AVF failure. However, the underlying mechanisms caused by sex differences in AVF failure remain unclear. (2) Methods: We performed analysis of DEGs and functional analysis with the dataset GSE119296 to reveal the biology underlying AVF failure. Immune responses were calculated using CIBERSORT. A protein–protein interaction network and hub gene were constructed using STRING and stepwise identification of potential drugs was performed online. (3) Results: Functional analysis showed that extracellular matrix reprogramming and PI3K-AKT pathway enrichment were significant in both male and female patients. COL1A1 was the hub gene in male patients, whereas CDK1 was the hub gene in female patients. Immune responses including γδ-T cells and mast cells are activated in female patients while no significant differences were noted in the male group. (4) Conclusions: In this study, we used a series of mature and recognized bioinformatic strategies to determine the following items: (1) Reveal the pathogenesis of AVF failure through HUB genes and signaling pathways between the different sexes. (2) Determine the relationship between sex differences in AVF failure and immune abnormalities. (3) Search for relevant sex-specific drugs targeting AVF failure.
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spelling pubmed-98625812023-01-22 Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis Hu, Ke Li, Yiqing Guo, Yi Cheng, Peng Li, Yuxuan Lu, Chanjun Cai, Chuanqi Wang, Weici J Cardiovasc Dev Dis Article (1) Background: Arteriovenous fistulas (AVFs) are the preferred access for hemodialysis. Unfortunately, about 60% of patients, especially female patients, fail to receive normal dialysis within one year after surgery because of AVF failure. However, the underlying mechanisms caused by sex differences in AVF failure remain unclear. (2) Methods: We performed analysis of DEGs and functional analysis with the dataset GSE119296 to reveal the biology underlying AVF failure. Immune responses were calculated using CIBERSORT. A protein–protein interaction network and hub gene were constructed using STRING and stepwise identification of potential drugs was performed online. (3) Results: Functional analysis showed that extracellular matrix reprogramming and PI3K-AKT pathway enrichment were significant in both male and female patients. COL1A1 was the hub gene in male patients, whereas CDK1 was the hub gene in female patients. Immune responses including γδ-T cells and mast cells are activated in female patients while no significant differences were noted in the male group. (4) Conclusions: In this study, we used a series of mature and recognized bioinformatic strategies to determine the following items: (1) Reveal the pathogenesis of AVF failure through HUB genes and signaling pathways between the different sexes. (2) Determine the relationship between sex differences in AVF failure and immune abnormalities. (3) Search for relevant sex-specific drugs targeting AVF failure. MDPI 2022-12-22 /pmc/articles/PMC9862581/ /pubmed/36661898 http://dx.doi.org/10.3390/jcdd10010003 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Ke
Li, Yiqing
Guo, Yi
Cheng, Peng
Li, Yuxuan
Lu, Chanjun
Cai, Chuanqi
Wang, Weici
Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis
title Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis
title_full Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis
title_fullStr Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis
title_full_unstemmed Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis
title_short Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis
title_sort sex differences in arteriovenous fistula failure: insights from bioinformatics analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862581/
https://www.ncbi.nlm.nih.gov/pubmed/36661898
http://dx.doi.org/10.3390/jcdd10010003
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