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3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors

SARS-CoV-2 nsp14 guanine-N7-methyltransferase plays an important role in the viral RNA translation process by catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to viral mRNA cap. We report a structure-guided design and synthesis of 3-(adenosylthio)benzoic acid derivatives as...

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Detalles Bibliográficos
Autores principales:	Bobileva, Olga, Bobrovs, Raitis, Sirma, Evelina Elva, Kanepe, Iveta, Bula, Anna L., Patetko, Liene, Ramata-Stunda, Anna, Grinberga, Solveiga, Jirgensons, Aigars, Jaudzems, Kristaps
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862586/ https://www.ncbi.nlm.nih.gov/pubmed/36677825 http://dx.doi.org/10.3390/molecules28020768

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