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Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients

Accumulating evidence suggests an association of the tryptophan–kynurenine (TRP-KYN) pathway with atherosclerosis and cardiovascular risk factors. In this cross-sectional analysis we investigated whether TRP-KYN pathway parameters are associated with 24 h blood pressure (BP) and other risk factors i...

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Autores principales: Theiler-Schwetz, Verena, Trummer, Christian, Grübler, Martin R., Keppel, Martin H., Zittermann, Armin, Tomaschitz, Andreas, März, Winfried, Meinitzer, Andreas, Pilz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862689/
https://www.ncbi.nlm.nih.gov/pubmed/36678127
http://dx.doi.org/10.3390/nu15020256
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author Theiler-Schwetz, Verena
Trummer, Christian
Grübler, Martin R.
Keppel, Martin H.
Zittermann, Armin
Tomaschitz, Andreas
März, Winfried
Meinitzer, Andreas
Pilz, Stefan
author_facet Theiler-Schwetz, Verena
Trummer, Christian
Grübler, Martin R.
Keppel, Martin H.
Zittermann, Armin
Tomaschitz, Andreas
März, Winfried
Meinitzer, Andreas
Pilz, Stefan
author_sort Theiler-Schwetz, Verena
collection PubMed
description Accumulating evidence suggests an association of the tryptophan–kynurenine (TRP-KYN) pathway with atherosclerosis and cardiovascular risk factors. In this cross-sectional analysis we investigated whether TRP-KYN pathway parameters are associated with 24 h blood pressure (BP) and other risk factors in patients with arterial hypertension from a tertiary care centre. In 490 participants, we found no significant and independent association of 24 h systolic and diastolic BP with parameters of the TRP-KYN pathway. However, linear regression analyses of HDL as dependent and TRP, KYN and quinolinic acid (QUIN) as explanatory variables adjusted for BMI and sex showed significant associations. These were found for KYN, BMI and sex (unstandardised beta coefficient −0.182, standard error 0.052, p < 0.001; −0.313 (0.078), p < 0.001; −0.180 (0.024), p < 0.001, respectively) as well as for QUIN, BMI and sex (−0.157 (0.038), p < 0.001; −0.321 (0.079), p < 0.001; −0.193 (0.024), p < 0.001, respectively). Smokers had significantly lower levels of KYN (2.36 µmol/L, IQR 2.01–2.98, versus 2.71 µmol/L, IQR 2.31–3.27, p < 0.001), QUIN (384 nmol/L, IQR 303–448, versus 451 nmol/L, IQR 369–575, p < 0.001) and KYN/TRP ratio (38.2, IQR 33.7–43.2, versus 43.1, IQR 37.5–50.9, p < 0.001) compared to non-smokers. We demonstrated that TRP/KYN pathway metabolites are associated with some cardiovascular risk factors, warranting further studies to elucidate the diagnostic and therapeutic potential of the TRP-KYN pathway for cardiovascular diseases.
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spelling pubmed-98626892023-01-22 Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients Theiler-Schwetz, Verena Trummer, Christian Grübler, Martin R. Keppel, Martin H. Zittermann, Armin Tomaschitz, Andreas März, Winfried Meinitzer, Andreas Pilz, Stefan Nutrients Article Accumulating evidence suggests an association of the tryptophan–kynurenine (TRP-KYN) pathway with atherosclerosis and cardiovascular risk factors. In this cross-sectional analysis we investigated whether TRP-KYN pathway parameters are associated with 24 h blood pressure (BP) and other risk factors in patients with arterial hypertension from a tertiary care centre. In 490 participants, we found no significant and independent association of 24 h systolic and diastolic BP with parameters of the TRP-KYN pathway. However, linear regression analyses of HDL as dependent and TRP, KYN and quinolinic acid (QUIN) as explanatory variables adjusted for BMI and sex showed significant associations. These were found for KYN, BMI and sex (unstandardised beta coefficient −0.182, standard error 0.052, p < 0.001; −0.313 (0.078), p < 0.001; −0.180 (0.024), p < 0.001, respectively) as well as for QUIN, BMI and sex (−0.157 (0.038), p < 0.001; −0.321 (0.079), p < 0.001; −0.193 (0.024), p < 0.001, respectively). Smokers had significantly lower levels of KYN (2.36 µmol/L, IQR 2.01–2.98, versus 2.71 µmol/L, IQR 2.31–3.27, p < 0.001), QUIN (384 nmol/L, IQR 303–448, versus 451 nmol/L, IQR 369–575, p < 0.001) and KYN/TRP ratio (38.2, IQR 33.7–43.2, versus 43.1, IQR 37.5–50.9, p < 0.001) compared to non-smokers. We demonstrated that TRP/KYN pathway metabolites are associated with some cardiovascular risk factors, warranting further studies to elucidate the diagnostic and therapeutic potential of the TRP-KYN pathway for cardiovascular diseases. MDPI 2023-01-04 /pmc/articles/PMC9862689/ /pubmed/36678127 http://dx.doi.org/10.3390/nu15020256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Theiler-Schwetz, Verena
Trummer, Christian
Grübler, Martin R.
Keppel, Martin H.
Zittermann, Armin
Tomaschitz, Andreas
März, Winfried
Meinitzer, Andreas
Pilz, Stefan
Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
title Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
title_full Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
title_fullStr Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
title_full_unstemmed Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
title_short Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
title_sort associations of parameters of the tryptophan–kynurenine pathway with cardiovascular risk factors in hypertensive patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862689/
https://www.ncbi.nlm.nih.gov/pubmed/36678127
http://dx.doi.org/10.3390/nu15020256
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