Down-regulation of KLF2 in lung fibroblasts is linked with COVID-19 immunofibrosis and restored by combined inhibition of NETs, JAK-1/2 and IL-6 signaling

Kruppel-like factor 2 (KLF2) has been linked with fibrosis and neutrophil-associated thromboinflammation; however, its role in COVID-19 remains elusive. We investigated the effect of disease microenvironment on the fibrotic potential of human lung fibroblasts (LFs) and its association with KLF2 expr...

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Detalles Bibliográficos
Autores principales: Chrysanthopoulou, Akrivi, Antoniadou, Christina, Natsi, Anastasia-Maria, Gavriilidis, Efstratios, Papadopoulos, Vasileios, Xingi, Evangelia, Didaskalou, Stylianos, Mikroulis, Dimitrios, Tsironidou, Victoria, Kambas, Konstantinos, Koffa, Maria, Skendros, Panagiotis, Ritis, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862710/
https://www.ncbi.nlm.nih.gov/pubmed/36693535
http://dx.doi.org/10.1016/j.clim.2023.109240

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