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Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pan...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862716/ https://www.ncbi.nlm.nih.gov/pubmed/36680252 http://dx.doi.org/10.3390/v15010212 |
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author | Sikkema, Reina S. de Bruin, Erwin Ramakers, Christian Bentvelsen, Robbert Li, Wentao Bosch, Berend-Jan Westerhuis, Brenda Haagmans, Bart Koopmans, Marion P. G. Fraaij, Pieter L. A. |
author_facet | Sikkema, Reina S. de Bruin, Erwin Ramakers, Christian Bentvelsen, Robbert Li, Wentao Bosch, Berend-Jan Westerhuis, Brenda Haagmans, Bart Koopmans, Marion P. G. Fraaij, Pieter L. A. |
author_sort | Sikkema, Reina S. |
collection | PubMed |
description | SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pandemic is largely lacking. Therefore, we set up a one-year serological survey in a large tertiary hospital in the Netherlands. We show that seasonal coronavirus seroprevalence significantly decreased in 2021 in children less than one year, most likely due to COVID-19 control measures. The SARS-CoV-2 seroprevalence in children and adolescents increased from 0.4% to 11.3%, the highest in adolescents. This implies higher exposure rates in adolescents as compared to the general population (>18 years old). It is clear that there have been significant changes in the circulation and subsequent immunity against most respiratory pathogens as a result of the mitigation measures. The implications on shorter as well as longer term are still largely unknown, but the impact of the SARS-CoV-2 pandemic and subsequent control measures will continue to affect the dynamics of other pathogens. |
format | Online Article Text |
id | pubmed-9862716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98627162023-01-22 Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands Sikkema, Reina S. de Bruin, Erwin Ramakers, Christian Bentvelsen, Robbert Li, Wentao Bosch, Berend-Jan Westerhuis, Brenda Haagmans, Bart Koopmans, Marion P. G. Fraaij, Pieter L. A. Viruses Brief Report SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pandemic is largely lacking. Therefore, we set up a one-year serological survey in a large tertiary hospital in the Netherlands. We show that seasonal coronavirus seroprevalence significantly decreased in 2021 in children less than one year, most likely due to COVID-19 control measures. The SARS-CoV-2 seroprevalence in children and adolescents increased from 0.4% to 11.3%, the highest in adolescents. This implies higher exposure rates in adolescents as compared to the general population (>18 years old). It is clear that there have been significant changes in the circulation and subsequent immunity against most respiratory pathogens as a result of the mitigation measures. The implications on shorter as well as longer term are still largely unknown, but the impact of the SARS-CoV-2 pandemic and subsequent control measures will continue to affect the dynamics of other pathogens. MDPI 2023-01-12 /pmc/articles/PMC9862716/ /pubmed/36680252 http://dx.doi.org/10.3390/v15010212 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Sikkema, Reina S. de Bruin, Erwin Ramakers, Christian Bentvelsen, Robbert Li, Wentao Bosch, Berend-Jan Westerhuis, Brenda Haagmans, Bart Koopmans, Marion P. G. Fraaij, Pieter L. A. Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands |
title | Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands |
title_full | Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands |
title_fullStr | Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands |
title_full_unstemmed | Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands |
title_short | Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands |
title_sort | reduced seasonal coronavirus antibody responses in children following covid-19 mitigation measures, the netherlands |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862716/ https://www.ncbi.nlm.nih.gov/pubmed/36680252 http://dx.doi.org/10.3390/v15010212 |
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