Cargando…

Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands

SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pan...

Descripción completa

Detalles Bibliográficos
Autores principales: Sikkema, Reina S., de Bruin, Erwin, Ramakers, Christian, Bentvelsen, Robbert, Li, Wentao, Bosch, Berend-Jan, Westerhuis, Brenda, Haagmans, Bart, Koopmans, Marion P. G., Fraaij, Pieter L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862716/
https://www.ncbi.nlm.nih.gov/pubmed/36680252
http://dx.doi.org/10.3390/v15010212
_version_ 1784875158575513600
author Sikkema, Reina S.
de Bruin, Erwin
Ramakers, Christian
Bentvelsen, Robbert
Li, Wentao
Bosch, Berend-Jan
Westerhuis, Brenda
Haagmans, Bart
Koopmans, Marion P. G.
Fraaij, Pieter L. A.
author_facet Sikkema, Reina S.
de Bruin, Erwin
Ramakers, Christian
Bentvelsen, Robbert
Li, Wentao
Bosch, Berend-Jan
Westerhuis, Brenda
Haagmans, Bart
Koopmans, Marion P. G.
Fraaij, Pieter L. A.
author_sort Sikkema, Reina S.
collection PubMed
description SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pandemic is largely lacking. Therefore, we set up a one-year serological survey in a large tertiary hospital in the Netherlands. We show that seasonal coronavirus seroprevalence significantly decreased in 2021 in children less than one year, most likely due to COVID-19 control measures. The SARS-CoV-2 seroprevalence in children and adolescents increased from 0.4% to 11.3%, the highest in adolescents. This implies higher exposure rates in adolescents as compared to the general population (>18 years old). It is clear that there have been significant changes in the circulation and subsequent immunity against most respiratory pathogens as a result of the mitigation measures. The implications on shorter as well as longer term are still largely unknown, but the impact of the SARS-CoV-2 pandemic and subsequent control measures will continue to affect the dynamics of other pathogens.
format Online
Article
Text
id pubmed-9862716
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98627162023-01-22 Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands Sikkema, Reina S. de Bruin, Erwin Ramakers, Christian Bentvelsen, Robbert Li, Wentao Bosch, Berend-Jan Westerhuis, Brenda Haagmans, Bart Koopmans, Marion P. G. Fraaij, Pieter L. A. Viruses Brief Report SARS-CoV-2 prevention and control measures did not only impact SARS-CoV-2 circulation, but also the timing and prevalence of other seasonal respiratory viruses. Especially in children, information on exposure and infections to seasonal coronaviruses as well as SARS-CoV-2 in the first year of the pandemic is largely lacking. Therefore, we set up a one-year serological survey in a large tertiary hospital in the Netherlands. We show that seasonal coronavirus seroprevalence significantly decreased in 2021 in children less than one year, most likely due to COVID-19 control measures. The SARS-CoV-2 seroprevalence in children and adolescents increased from 0.4% to 11.3%, the highest in adolescents. This implies higher exposure rates in adolescents as compared to the general population (>18 years old). It is clear that there have been significant changes in the circulation and subsequent immunity against most respiratory pathogens as a result of the mitigation measures. The implications on shorter as well as longer term are still largely unknown, but the impact of the SARS-CoV-2 pandemic and subsequent control measures will continue to affect the dynamics of other pathogens. MDPI 2023-01-12 /pmc/articles/PMC9862716/ /pubmed/36680252 http://dx.doi.org/10.3390/v15010212 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Sikkema, Reina S.
de Bruin, Erwin
Ramakers, Christian
Bentvelsen, Robbert
Li, Wentao
Bosch, Berend-Jan
Westerhuis, Brenda
Haagmans, Bart
Koopmans, Marion P. G.
Fraaij, Pieter L. A.
Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
title Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
title_full Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
title_fullStr Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
title_full_unstemmed Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
title_short Reduced Seasonal Coronavirus Antibody Responses in Children Following COVID-19 Mitigation Measures, The Netherlands
title_sort reduced seasonal coronavirus antibody responses in children following covid-19 mitigation measures, the netherlands
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862716/
https://www.ncbi.nlm.nih.gov/pubmed/36680252
http://dx.doi.org/10.3390/v15010212
work_keys_str_mv AT sikkemareinas reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT debruinerwin reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT ramakerschristian reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT bentvelsenrobbert reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT liwentao reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT boschberendjan reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT westerhuisbrenda reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT haagmansbart reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT koopmansmarionpg reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands
AT fraaijpieterla reducedseasonalcoronavirusantibodyresponsesinchildrenfollowingcovid19mitigationmeasuresthenetherlands