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Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over

Previous studies have generally reported the association between serum uric acid (SUA) and diabetic complications, but large-scale research exploring the above association in U.S. adults with diabetes is limited. To explore the association between SUA and chronic complications of diabetes among U.S....

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Autores principales: Han, Yingdong, Wang, Shuolin, Zhao, He, Cao, Yu, Han, Xinxin, Di, Hong, Yin, Yue, Wu, Juan, Zhang, Yun, Zeng, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862742/
https://www.ncbi.nlm.nih.gov/pubmed/36675654
http://dx.doi.org/10.3390/jcm12020725
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author Han, Yingdong
Wang, Shuolin
Zhao, He
Cao, Yu
Han, Xinxin
Di, Hong
Yin, Yue
Wu, Juan
Zhang, Yun
Zeng, Xuejun
author_facet Han, Yingdong
Wang, Shuolin
Zhao, He
Cao, Yu
Han, Xinxin
Di, Hong
Yin, Yue
Wu, Juan
Zhang, Yun
Zeng, Xuejun
author_sort Han, Yingdong
collection PubMed
description Previous studies have generally reported the association between serum uric acid (SUA) and diabetic complications, but large-scale research exploring the above association in U.S. adults with diabetes is limited. To explore the association between SUA and chronic complications of diabetes among U.S. patients aged ≥40, we used data from the National Health and Nutrition Examination Survey 1999–2008. SUA was divided into three levels: T1 (SUA ≥ 420 μmol/L), T2 (300 ≤ SUA < 420 μmol/L), and T3 (SUA < 300 μmol/L). Binary logistic regression and restricted cubic spline analysis were applied to evaluate the association between SUA and chronic complications of diabetes. A trend test was performed as the SUA increased substantially. After full-adjusted confounding factors, patients in the T3 group had a lower risk of diabetic kidney disease, cardiovascular disease, and peripheral neuropathy compared with the T1 group, with a OR (95% CIs) of 0.33 (0.21–0.52), 0.56 (0.36–0.87), and 0.49 (0.27–0.89), respectively. The restricted cubic spline showed a significant positive relationship between SUA and cardiovascular disease and diabetic kidney disease in diabetes patients, but not peripheral neuropathy. Maintaining a SUA of less than 300 μmol/L might be protective against the risk of cardiovascular disease, diabetic kidney disease, and peripheral neuropathy other than diabetic retinopathy compared with a SUA of more than 420 μmol/L in U.S. diabetes patients aged 40 and over.
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spelling pubmed-98627422023-01-22 Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over Han, Yingdong Wang, Shuolin Zhao, He Cao, Yu Han, Xinxin Di, Hong Yin, Yue Wu, Juan Zhang, Yun Zeng, Xuejun J Clin Med Article Previous studies have generally reported the association between serum uric acid (SUA) and diabetic complications, but large-scale research exploring the above association in U.S. adults with diabetes is limited. To explore the association between SUA and chronic complications of diabetes among U.S. patients aged ≥40, we used data from the National Health and Nutrition Examination Survey 1999–2008. SUA was divided into three levels: T1 (SUA ≥ 420 μmol/L), T2 (300 ≤ SUA < 420 μmol/L), and T3 (SUA < 300 μmol/L). Binary logistic regression and restricted cubic spline analysis were applied to evaluate the association between SUA and chronic complications of diabetes. A trend test was performed as the SUA increased substantially. After full-adjusted confounding factors, patients in the T3 group had a lower risk of diabetic kidney disease, cardiovascular disease, and peripheral neuropathy compared with the T1 group, with a OR (95% CIs) of 0.33 (0.21–0.52), 0.56 (0.36–0.87), and 0.49 (0.27–0.89), respectively. The restricted cubic spline showed a significant positive relationship between SUA and cardiovascular disease and diabetic kidney disease in diabetes patients, but not peripheral neuropathy. Maintaining a SUA of less than 300 μmol/L might be protective against the risk of cardiovascular disease, diabetic kidney disease, and peripheral neuropathy other than diabetic retinopathy compared with a SUA of more than 420 μmol/L in U.S. diabetes patients aged 40 and over. MDPI 2023-01-16 /pmc/articles/PMC9862742/ /pubmed/36675654 http://dx.doi.org/10.3390/jcm12020725 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Han, Yingdong
Wang, Shuolin
Zhao, He
Cao, Yu
Han, Xinxin
Di, Hong
Yin, Yue
Wu, Juan
Zhang, Yun
Zeng, Xuejun
Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
title Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
title_full Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
title_fullStr Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
title_full_unstemmed Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
title_short Lower Serum Uric Acid Levels May Lower the Incidence of Diabetic Chronic Complications in U.S. Adults Aged 40 and Over
title_sort lower serum uric acid levels may lower the incidence of diabetic chronic complications in u.s. adults aged 40 and over
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862742/
https://www.ncbi.nlm.nih.gov/pubmed/36675654
http://dx.doi.org/10.3390/jcm12020725
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