Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly

Phosphodiesterases (PDEs) are a superfamily of evolutionarily conserved cyclic nucleotide (cAMP/cGMP)-hydrolyzing enzymes, components of transduction pathways regulating crucial aspects of cell life. Within this family, the cGMP-dependent PDE5 is the major hydrolyzing enzyme in many mammalian tissue...

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Detalles Bibliográficos
Autores principales: Giorgi, Mauro, Miele, Adriana Erica, Cardarelli, Silvia, Giorgi, Alessandra, Massimi, Mara, Biagioni, Stefano, Saliola, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862819/
https://www.ncbi.nlm.nih.gov/pubmed/36674621
http://dx.doi.org/10.3390/ijms24021108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862819/
https://www.ncbi.nlm.nih.gov/pubmed/36674621
http://dx.doi.org/10.3390/ijms24021108

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