Two New Compounds from the Fungus Xylaria nigripes

In the process of discovering more neural-system-related bioactive compounds from Xylaria nigripes, xylariamino acid A (1), a new amino acid derivative, and a new isovaleric acid phenethyl ester (2) were isolated and identified. Their structures and absolute configurations were determined by analyse...

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Autores principales: Long, Hongping, Zhou, Siqian, Li, Lanqing, Li, Jing, Liu, Jikai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862878/
https://www.ncbi.nlm.nih.gov/pubmed/36677568
http://dx.doi.org/10.3390/molecules28020508
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author Long, Hongping
Zhou, Siqian
Li, Lanqing
Li, Jing
Liu, Jikai
author_facet Long, Hongping
Zhou, Siqian
Li, Lanqing
Li, Jing
Liu, Jikai
author_sort Long, Hongping
collection PubMed
description In the process of discovering more neural-system-related bioactive compounds from Xylaria nigripes, xylariamino acid A (1), a new amino acid derivative, and a new isovaleric acid phenethyl ester (2) were isolated and identified. Their structures and absolute configurations were determined by analyses of IR, HRESIMS, NMR spectroscopic data, and gauge-independent atomic orbital (GIAO) NMR calculation, as well as electronic circular dichroism (ECD) calculation. The isolated compounds were evaluated for their neuroprotective effects against damage to PC12 cells by oxygen and glucose deprivation (OGD). Compounds 1 and 2 can increase the viability of OGD-induced PC12 cells at all tested concentrations. Moreover, compound 2 (1 μmol L(−1)) can significantly reduce the percentage of apoptotic cells.
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spelling pubmed-98628782023-01-22 Two New Compounds from the Fungus Xylaria nigripes Long, Hongping Zhou, Siqian Li, Lanqing Li, Jing Liu, Jikai Molecules Article In the process of discovering more neural-system-related bioactive compounds from Xylaria nigripes, xylariamino acid A (1), a new amino acid derivative, and a new isovaleric acid phenethyl ester (2) were isolated and identified. Their structures and absolute configurations were determined by analyses of IR, HRESIMS, NMR spectroscopic data, and gauge-independent atomic orbital (GIAO) NMR calculation, as well as electronic circular dichroism (ECD) calculation. The isolated compounds were evaluated for their neuroprotective effects against damage to PC12 cells by oxygen and glucose deprivation (OGD). Compounds 1 and 2 can increase the viability of OGD-induced PC12 cells at all tested concentrations. Moreover, compound 2 (1 μmol L(−1)) can significantly reduce the percentage of apoptotic cells. MDPI 2023-01-04 /pmc/articles/PMC9862878/ /pubmed/36677568 http://dx.doi.org/10.3390/molecules28020508 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Hongping
Zhou, Siqian
Li, Lanqing
Li, Jing
Liu, Jikai
Two New Compounds from the Fungus Xylaria nigripes
title Two New Compounds from the Fungus Xylaria nigripes
title_full Two New Compounds from the Fungus Xylaria nigripes
title_fullStr Two New Compounds from the Fungus Xylaria nigripes
title_full_unstemmed Two New Compounds from the Fungus Xylaria nigripes
title_short Two New Compounds from the Fungus Xylaria nigripes
title_sort two new compounds from the fungus xylaria nigripes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862878/
https://www.ncbi.nlm.nih.gov/pubmed/36677568
http://dx.doi.org/10.3390/molecules28020508
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