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New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)
Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 un...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862887/ https://www.ncbi.nlm.nih.gov/pubmed/36675001 http://dx.doi.org/10.3390/ijms24021487 |
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| author | Li, Sheng Han, Ling-Ling Huang, Ke-Pu Ma, Ye-Han Guo, Ling-Li Guo, Yarong Ran, Xiaoqian Yao, Yong-Gang Hao, Xiao-Jiang Luo, Rongcan Zhang, Yu |
| author_facet | Li, Sheng Han, Ling-Ling Huang, Ke-Pu Ma, Ye-Han Guo, Ling-Li Guo, Yarong Ran, Xiaoqian Yao, Yong-Gang Hao, Xiao-Jiang Luo, Rongcan Zhang, Yu |
| author_sort | Li, Sheng |
| collection | PubMed |
| description | Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1–3 all reduce Aβ42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer’s disease [AD] associated with BACE1-, NCSTN-, GSK3β-, and CDK5-mediated pathways, suggesting these alkaloids’ potential against AD. |
| format | Online Article Text |
| id | pubmed-9862887 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98628872023-01-22 New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) Li, Sheng Han, Ling-Ling Huang, Ke-Pu Ma, Ye-Han Guo, Ling-Li Guo, Yarong Ran, Xiaoqian Yao, Yong-Gang Hao, Xiao-Jiang Luo, Rongcan Zhang, Yu Int J Mol Sci Article Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1–3 all reduce Aβ42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer’s disease [AD] associated with BACE1-, NCSTN-, GSK3β-, and CDK5-mediated pathways, suggesting these alkaloids’ potential against AD. MDPI 2023-01-12 /pmc/articles/PMC9862887/ /pubmed/36675001 http://dx.doi.org/10.3390/ijms24021487 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Li, Sheng Han, Ling-Ling Huang, Ke-Pu Ma, Ye-Han Guo, Ling-Li Guo, Yarong Ran, Xiaoqian Yao, Yong-Gang Hao, Xiao-Jiang Luo, Rongcan Zhang, Yu New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| title | New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| title_full | New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| title_fullStr | New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| title_full_unstemmed | New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| title_short | New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| title_sort | new monoterpenoid indole alkaloids from tabernaemontana crassa inhibit β-amyloid42 production and phospho-tau (thr217) |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862887/ https://www.ncbi.nlm.nih.gov/pubmed/36675001 http://dx.doi.org/10.3390/ijms24021487 |
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