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Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis

Mass vaccination initiatives are underway worldwide, and a considerable percentage of the world’s population is now vaccinated. This study examined the association of COVID-19 deaths per 1000 cases with a fully vaccinated population. The global median deaths per 1000 cases were 15.68 (IQR 9.84, 25.8...

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Autores principales: Hoxha, Ilir, Agahi, Riaz, Bimbashi, Altina, Aliu, Mrika, Raka, Lul, Bajraktari, Ilirjana, Beqiri, Petrit, Adams, Lisa V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862920/
https://www.ncbi.nlm.nih.gov/pubmed/36679919
http://dx.doi.org/10.3390/vaccines11010074
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author Hoxha, Ilir
Agahi, Riaz
Bimbashi, Altina
Aliu, Mrika
Raka, Lul
Bajraktari, Ilirjana
Beqiri, Petrit
Adams, Lisa V.
author_facet Hoxha, Ilir
Agahi, Riaz
Bimbashi, Altina
Aliu, Mrika
Raka, Lul
Bajraktari, Ilirjana
Beqiri, Petrit
Adams, Lisa V.
author_sort Hoxha, Ilir
collection PubMed
description Mass vaccination initiatives are underway worldwide, and a considerable percentage of the world’s population is now vaccinated. This study examined the association of COVID-19 deaths per 1000 cases with a fully vaccinated population. The global median deaths per 1000 cases were 15.68 (IQR 9.84, 25.87) after 6 months of vaccinations and 11.96 (IQR 6.08, 20.63) after 12 months. Across 164 countries, we found significant variations in vaccination levels of populations, booster doses, and mortality, with higher vaccine coverage and lower mortality in high-income countries. Several regression models were performed to test the association between vaccination and COVID-19 mortality. Control variables were used to account for confounding variables. A 10-percentage-point increase in vaccination was associated with an 18.1% decrease in mortality after 6 months (95%CI, 7.4–28.8%) and a 16.8% decrease after 12 months (95%CI, 6.9–26.7%). A 10-percentage-point increase in booster vaccination rates was associated with a 33.1% decrease in COVID-19 mortality (95%CI, 16.0–50.2%). This relationship is present in most analyses by country income groups with variations in the effect size. Efforts are needed to reduce vaccine hesitancy while ensuring suitable infrastructure and supply to enable all countries to increase their vaccination rates.
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spelling pubmed-98629202023-01-22 Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis Hoxha, Ilir Agahi, Riaz Bimbashi, Altina Aliu, Mrika Raka, Lul Bajraktari, Ilirjana Beqiri, Petrit Adams, Lisa V. Vaccines (Basel) Article Mass vaccination initiatives are underway worldwide, and a considerable percentage of the world’s population is now vaccinated. This study examined the association of COVID-19 deaths per 1000 cases with a fully vaccinated population. The global median deaths per 1000 cases were 15.68 (IQR 9.84, 25.87) after 6 months of vaccinations and 11.96 (IQR 6.08, 20.63) after 12 months. Across 164 countries, we found significant variations in vaccination levels of populations, booster doses, and mortality, with higher vaccine coverage and lower mortality in high-income countries. Several regression models were performed to test the association between vaccination and COVID-19 mortality. Control variables were used to account for confounding variables. A 10-percentage-point increase in vaccination was associated with an 18.1% decrease in mortality after 6 months (95%CI, 7.4–28.8%) and a 16.8% decrease after 12 months (95%CI, 6.9–26.7%). A 10-percentage-point increase in booster vaccination rates was associated with a 33.1% decrease in COVID-19 mortality (95%CI, 16.0–50.2%). This relationship is present in most analyses by country income groups with variations in the effect size. Efforts are needed to reduce vaccine hesitancy while ensuring suitable infrastructure and supply to enable all countries to increase their vaccination rates. MDPI 2022-12-28 /pmc/articles/PMC9862920/ /pubmed/36679919 http://dx.doi.org/10.3390/vaccines11010074 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hoxha, Ilir
Agahi, Riaz
Bimbashi, Altina
Aliu, Mrika
Raka, Lul
Bajraktari, Ilirjana
Beqiri, Petrit
Adams, Lisa V.
Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
title Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
title_full Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
title_fullStr Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
title_full_unstemmed Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
title_short Higher COVID-19 Vaccination Rates Are Associated with Lower COVID-19 Mortality: A Global Analysis
title_sort higher covid-19 vaccination rates are associated with lower covid-19 mortality: a global analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862920/
https://www.ncbi.nlm.nih.gov/pubmed/36679919
http://dx.doi.org/10.3390/vaccines11010074
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