Cargando…

Optimization of an Injectable Hydrogel Depot System for the Controlled Release of Retinal-Targeted Hybrid Nanoparticles

A drawback in the development of treatments that can reach the retina is the presence of barriers in the eye that restrain compounds from reaching the target. Intravitreal injections hold promise for retinal delivery, but the natural defenses in the vitreous can rapidly degrade or eliminate therapeu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ottonelli, Ilaria, Bighinati, Andrea, Adani, Elisa, Loll, François, Caraffi, Riccardo, Vandelli, Maria Angela, Boury, Frank, Tosi, Giovanni, Duskey, Jason Thomas, Marigo, Valeria, Ruozi, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862926/ https://www.ncbi.nlm.nih.gov/pubmed/36678654 http://dx.doi.org/10.3390/pharmaceutics15010025

Ejemplares similares

Tunneling Nanotubes: A New Target for Nanomedicine?
por: Ottonelli, Ilaria, et al.
Publicado: (2022)

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization
por: Rodà, Francesca, et al.
Publicado: (2023)

Quantitative comparison of the protein corona of nanoparticles with different matrices
por: Ottonelli, Ilaria, et al.
Publicado: (2022)

Corrigendum to “Quantitative comparison of the protein corona of nanoparticles with different matrices” [Int J Pharm X 2022 Oct 21;4: 100136]
por: Ottonelli, Ilaria, et al.
Publicado: (2023)

Glioblastoma Multiforme Selective Nanomedicines for Improved Anti-Cancer Treatments
por: Duskey, Jason Thomas, et al.
Publicado: (2022)

Enzyme Stability in Nanoparticle Preparations Part 1: Bovine Serum Albumin Improves Enzyme Function
por: Duskey, Jason Thomas, et al.
Publicado: (2020)

“Combo” Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal Cord Injury
por: Moretti, Marzia, et al.
Publicado: (2023)

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications
por: Duskey, Jason Thomas, et al.
Publicado: (2020)

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines
por: Rinaldi, Arianna, et al.
Publicado: (2022)

Tween(®) Preserves Enzyme Activity and Stability in PLGA Nanoparticles
por: Duskey, Jason Thomas, et al.
Publicado: (2021)

Microfluidic Technology for the Production of Hybrid Nanomedicines
por: Ottonelli, Ilaria, et al.
Publicado: (2021)

New In Vitro Cellular Model for Molecular Studies of Retinitis Pigmentosa
por: Huang, Li, et al.
Publicado: (2021)

Targeting Brain Disease in MPSII: Preclinical Evaluation of IDS-Loaded PLGA Nanoparticles
por: Rigon, Laura, et al.
Publicado: (2019)

PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study
por: Hoyos-Ceballos, Gina P., et al.
Publicado: (2020)

Nanomedicine against Aβ Aggregation by β–Sheet Breaker Peptide Delivery: In Vitro Evidence
por: Pederzoli, Francesca, et al.
Publicado: (2019)

Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for Glioblastoma Treatment
por: Oddone, Natalia, et al.
Publicado: (2020)

In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection
por: Ju, Hyeon Jin, et al.
Publicado: (2020)

Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease
por: Birolini, Giulia, et al.
Publicado: (2023)

Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma
por: Zhao, Xiyue, et al.
Publicado: (2019)

Dynamic Covalent Dextran Hydrogels as Injectable, Self-Adjuvating Peptide Vaccine Depots
por: Fan, Bowen, et al.
Publicado: (2023)

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders
por: Djoudi, Amel, et al.
Publicado: (2022)

Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot
por: Sarode, Bhagyesh R., et al.
Publicado: (2016)

“The Toxic Depot”: Parenteral Insecticide Injection
por: Jacob, Jerry, et al.
Publicado: (2022)

In Situ Crosslinked Hydrogel Depot for Sustained Antibody Release Improves Immune Checkpoint Blockade Cancer Immunotherapy
por: Kim, Jihoon, et al.
Publicado: (2021)

Programming Injectable DNA Hydrogels Yields Tumor Microenvironment‐Activatable and Immune‐Instructive Depots for Augmented Chemo‐Immunotherapy
por: Fan, Yu, et al.
Publicado: (2023)

Injectable Biodegradable Silica Depot: Two Months of Sustained Release of the Blood Glucose Lowering Peptide, Pramlintide
por: Tyagi, Puneet, et al.
Publicado: (2022)

Postinjection Delirium/Sedation Syndrome with Olanzapine Depot Injection
por: Sarangula, Sadhvi Mythili, et al.
Publicado: (2016)

Injectables and Depots to Prolong Drug Action of Proteins and Peptides
por: Ibeanu, Nkiruka, et al.
Publicado: (2020)

Targeting molecular pathways for the treatment of inherited retinal degeneration
por: Kutluer, Meltem, et al.
Publicado: (2020)

Development of Novel Zn(2+) Loaded Nanoparticles Designed for Cell-Type Targeted Drug Release in CNS Neurons: In Vitro Evidences
por: Grabrucker, Andreas M., et al.
Publicado: (2011)

Injectable Polypeptide Hydrogel Depots Containing Dual Immune Checkpoint Inhibitors and Doxorubicin for Improved Tumor Immunotherapy and Post-Surgical Tumor Treatment
por: Chen, Zhixiong, et al.
Publicado: (2023)

Leuprorelin depot injection: patient considerations in the management of prostatic cancer
por: Abouelfadel, Zinelabidine, et al.
Publicado: (2008)

Testosterone depot injection in male hypogonadism: a critical appraisal
por: Yassin, Aksam A, et al.
Publicado: (2007)

Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs
por: Blizzard, Charles, et al.
Publicado: (2016)

Thermosensitive PLGA–PEG–PLGA Hydrogel as Depot Matrix for Allergen-Specific Immunotherapy
por: Heine, Sonja, et al.
Publicado: (2022)

Injectable In-Situ Forming Depot Based on PLGA and PLGA-PEG-PLGA for Sustained-Release of Risperidone: In Vitro Evaluation and Pharmacokinetics in Rabbits
por: Rezaeian Shiadeh, Seyedeh Nesa, et al.
Publicado: (2023)

Injectable Thermosensitive Hydrogels for a Sustained Release of Iron Nanochelators
por: Park, Seung Hun, et al.
Publicado: (2022)

Sustained release of therapeutic gene by injectable hydrogel for hepatocellular carcinoma
por: Xu, Shuangta, et al.
Publicado: (2023)

Schizophrenia relapse and the clinical usefulness of once-monthly aripiprazole depot injection
por: Wang, Sheng-Min, et al.
Publicado: (2014)

Gluteal Subcutaneous Atrophy After Depot Steroid Injection for Allergic Rhinitis
por: Ameratunga, Rohan
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ovtg3gba3qbnv7qv9cmeld7jsl