Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels

In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength,...

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Detalles Bibliográficos
Autores principales: Tang, Zuwu, Yu, Meiqiong, Mondal, Ajoy Kanti, Lin, Xinxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863020/
https://www.ncbi.nlm.nih.gov/pubmed/36679152
http://dx.doi.org/10.3390/polym15020271
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author Tang, Zuwu
Yu, Meiqiong
Mondal, Ajoy Kanti
Lin, Xinxing
author_facet Tang, Zuwu
Yu, Meiqiong
Mondal, Ajoy Kanti
Lin, Xinxing
author_sort Tang, Zuwu
collection PubMed
description In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, and cytocompatibility were investigated. Scanning electron microscope images (SEM) displayed the hydrogel pore sizes, ranging from 20 to 100 μm. The composite hydrogel exhibited excellent porosity of 95.1%, compression strength of 5.2 MPa, lap shear strength of 21 kPa on porcine skin, and mass loss of 16.0%. In addition, the composite hydrogel possessed good relative cell activity of 97%. The PDA/CS/PVA hydrogel is cytocompatible as a starting point, and it can be further investigated in tissue engineering.
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spelling pubmed-98630202023-01-22 Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels Tang, Zuwu Yu, Meiqiong Mondal, Ajoy Kanti Lin, Xinxing Polymers (Basel) Article In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, and cytocompatibility were investigated. Scanning electron microscope images (SEM) displayed the hydrogel pore sizes, ranging from 20 to 100 μm. The composite hydrogel exhibited excellent porosity of 95.1%, compression strength of 5.2 MPa, lap shear strength of 21 kPa on porcine skin, and mass loss of 16.0%. In addition, the composite hydrogel possessed good relative cell activity of 97%. The PDA/CS/PVA hydrogel is cytocompatible as a starting point, and it can be further investigated in tissue engineering. MDPI 2023-01-05 /pmc/articles/PMC9863020/ /pubmed/36679152 http://dx.doi.org/10.3390/polym15020271 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tang, Zuwu
Yu, Meiqiong
Mondal, Ajoy Kanti
Lin, Xinxing
Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
title Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
title_full Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
title_fullStr Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
title_full_unstemmed Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
title_short Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
title_sort porous scaffolds based on polydopamine/chondroitin sulfate/polyvinyl alcohol composite hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863020/
https://www.ncbi.nlm.nih.gov/pubmed/36679152
http://dx.doi.org/10.3390/polym15020271
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AT yumeiqiong porousscaffoldsbasedonpolydopaminechondroitinsulfatepolyvinylalcoholcompositehydrogels
AT mondalajoykanti porousscaffoldsbasedonpolydopaminechondroitinsulfatepolyvinylalcoholcompositehydrogels
AT linxinxing porousscaffoldsbasedonpolydopaminechondroitinsulfatepolyvinylalcoholcompositehydrogels

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