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Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants

Purpose: The Omicron subvariant BA.1 of SARS-CoV-2 was first detected in November 2021 and quickly spread worldwide, displacing the Delta variant. In this work, a characterization of the spread of this variant in Mexico is presented. Methods: The time to fixation of BA.1, the diversity of Delta subl...

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Autores principales: Zárate, Selene, Taboada, Blanca, Rosales-Rivera, Mauricio, García-López, Rodrigo, Muñoz-Medina, José Esteban, Sanchez-Flores, Alejandro, Herrera-Estrella, Alfredo, Gómez-Gil, Bruno, Selem Mojica, Nelly, Salas-Lais, Angel Gustavo, Vazquez-Perez, Joel Armando, Cabrera-Gaytán, David Alejandro, Fernandes-Matano, Larissa, Uribe-Noguez, Luis Antonio, Chale-Dzul, Juan Bautista, Maldonado Meza, Brenda Irasema, Mejía-Nepomuceno, Fidencio, Pérez-Padilla, Rogelio, Gutiérrez-Ríos, Rosa María, Loza, Antonio, Roche, Benjamin, López, Susana, Arias, Carlos F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863047/
https://www.ncbi.nlm.nih.gov/pubmed/36680283
http://dx.doi.org/10.3390/v15010243
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author Zárate, Selene
Taboada, Blanca
Rosales-Rivera, Mauricio
García-López, Rodrigo
Muñoz-Medina, José Esteban
Sanchez-Flores, Alejandro
Herrera-Estrella, Alfredo
Gómez-Gil, Bruno
Selem Mojica, Nelly
Salas-Lais, Angel Gustavo
Vazquez-Perez, Joel Armando
Cabrera-Gaytán, David Alejandro
Fernandes-Matano, Larissa
Uribe-Noguez, Luis Antonio
Chale-Dzul, Juan Bautista
Maldonado Meza, Brenda Irasema
Mejía-Nepomuceno, Fidencio
Pérez-Padilla, Rogelio
Gutiérrez-Ríos, Rosa María
Loza, Antonio
Roche, Benjamin
López, Susana
Arias, Carlos F.
author_facet Zárate, Selene
Taboada, Blanca
Rosales-Rivera, Mauricio
García-López, Rodrigo
Muñoz-Medina, José Esteban
Sanchez-Flores, Alejandro
Herrera-Estrella, Alfredo
Gómez-Gil, Bruno
Selem Mojica, Nelly
Salas-Lais, Angel Gustavo
Vazquez-Perez, Joel Armando
Cabrera-Gaytán, David Alejandro
Fernandes-Matano, Larissa
Uribe-Noguez, Luis Antonio
Chale-Dzul, Juan Bautista
Maldonado Meza, Brenda Irasema
Mejía-Nepomuceno, Fidencio
Pérez-Padilla, Rogelio
Gutiérrez-Ríos, Rosa María
Loza, Antonio
Roche, Benjamin
López, Susana
Arias, Carlos F.
author_sort Zárate, Selene
collection PubMed
description Purpose: The Omicron subvariant BA.1 of SARS-CoV-2 was first detected in November 2021 and quickly spread worldwide, displacing the Delta variant. In this work, a characterization of the spread of this variant in Mexico is presented. Methods: The time to fixation of BA.1, the diversity of Delta sublineages, the population density, and the level of virus circulation during the inter-wave interval were determined to analyze differences in BA.1 spread. Results: BA.1 began spreading during the first week of December 2021 and became dominant in the next three weeks, causing the fourth COVID-19 epidemiological surge in Mexico. Unlike previous variants, BA.1 did not exhibit a geographically distinct circulation pattern. However, a regional difference in the speed of the replacement of the Delta variant was observed. Conclusions: Viral diversity and the relative abundance of the virus in a particular area around the time of the introduction of a new lineage seem to have influenced the spread dynamics, in addition to population density. Nonetheless, if there is a significant difference in the fitness of the variants, or if the time allowed for the competition is sufficiently long, it seems the fitter virus will eventually become dominant, as observed in the eventual dominance of the BA.1.x variant in Mexico.
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spelling pubmed-98630472023-01-22 Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants Zárate, Selene Taboada, Blanca Rosales-Rivera, Mauricio García-López, Rodrigo Muñoz-Medina, José Esteban Sanchez-Flores, Alejandro Herrera-Estrella, Alfredo Gómez-Gil, Bruno Selem Mojica, Nelly Salas-Lais, Angel Gustavo Vazquez-Perez, Joel Armando Cabrera-Gaytán, David Alejandro Fernandes-Matano, Larissa Uribe-Noguez, Luis Antonio Chale-Dzul, Juan Bautista Maldonado Meza, Brenda Irasema Mejía-Nepomuceno, Fidencio Pérez-Padilla, Rogelio Gutiérrez-Ríos, Rosa María Loza, Antonio Roche, Benjamin López, Susana Arias, Carlos F. Viruses Article Purpose: The Omicron subvariant BA.1 of SARS-CoV-2 was first detected in November 2021 and quickly spread worldwide, displacing the Delta variant. In this work, a characterization of the spread of this variant in Mexico is presented. Methods: The time to fixation of BA.1, the diversity of Delta sublineages, the population density, and the level of virus circulation during the inter-wave interval were determined to analyze differences in BA.1 spread. Results: BA.1 began spreading during the first week of December 2021 and became dominant in the next three weeks, causing the fourth COVID-19 epidemiological surge in Mexico. Unlike previous variants, BA.1 did not exhibit a geographically distinct circulation pattern. However, a regional difference in the speed of the replacement of the Delta variant was observed. Conclusions: Viral diversity and the relative abundance of the virus in a particular area around the time of the introduction of a new lineage seem to have influenced the spread dynamics, in addition to population density. Nonetheless, if there is a significant difference in the fitness of the variants, or if the time allowed for the competition is sufficiently long, it seems the fitter virus will eventually become dominant, as observed in the eventual dominance of the BA.1.x variant in Mexico. MDPI 2023-01-15 /pmc/articles/PMC9863047/ /pubmed/36680283 http://dx.doi.org/10.3390/v15010243 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zárate, Selene
Taboada, Blanca
Rosales-Rivera, Mauricio
García-López, Rodrigo
Muñoz-Medina, José Esteban
Sanchez-Flores, Alejandro
Herrera-Estrella, Alfredo
Gómez-Gil, Bruno
Selem Mojica, Nelly
Salas-Lais, Angel Gustavo
Vazquez-Perez, Joel Armando
Cabrera-Gaytán, David Alejandro
Fernandes-Matano, Larissa
Uribe-Noguez, Luis Antonio
Chale-Dzul, Juan Bautista
Maldonado Meza, Brenda Irasema
Mejía-Nepomuceno, Fidencio
Pérez-Padilla, Rogelio
Gutiérrez-Ríos, Rosa María
Loza, Antonio
Roche, Benjamin
López, Susana
Arias, Carlos F.
Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
title Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
title_full Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
title_fullStr Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
title_full_unstemmed Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
title_short Omicron-BA.1 Dispersion Rates in Mexico Varied According to the Regional Epidemic Patterns and the Diversity of Local Delta Subvariants
title_sort omicron-ba.1 dispersion rates in mexico varied according to the regional epidemic patterns and the diversity of local delta subvariants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863047/
https://www.ncbi.nlm.nih.gov/pubmed/36680283
http://dx.doi.org/10.3390/v15010243
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