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Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb

During November to December 2020, a high rate of COVID-19-associated pneumonia with bacterial superinfections due to multidrug-resistant (MDR) pathogens was recorded in a COVID-19 hospital in Zagreb. This study analyzed the causative agents of bacterial superinfections among patients with serious fo...

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Autores principales: Bedenić, Branka, Bratić, Vesna, Mihaljević, Slobodan, Lukić, Anita, Vidović, Karlo, Reiner, Krešimir, Schöenthaler, Silvia, Barišić, Ivan, Zarfel, Gernot, Grisold, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863123/
https://www.ncbi.nlm.nih.gov/pubmed/36678465
http://dx.doi.org/10.3390/pathogens12010117
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author Bedenić, Branka
Bratić, Vesna
Mihaljević, Slobodan
Lukić, Anita
Vidović, Karlo
Reiner, Krešimir
Schöenthaler, Silvia
Barišić, Ivan
Zarfel, Gernot
Grisold, Andrea
author_facet Bedenić, Branka
Bratić, Vesna
Mihaljević, Slobodan
Lukić, Anita
Vidović, Karlo
Reiner, Krešimir
Schöenthaler, Silvia
Barišić, Ivan
Zarfel, Gernot
Grisold, Andrea
author_sort Bedenić, Branka
collection PubMed
description During November to December 2020, a high rate of COVID-19-associated pneumonia with bacterial superinfections due to multidrug-resistant (MDR) pathogens was recorded in a COVID-19 hospital in Zagreb. This study analyzed the causative agents of bacterial superinfections among patients with serious forms of COVID-19. In total, 118 patients were hospitalized in the intensive care unit (ICU) of the COVID-19 hospital. Forty-six out of 118 patients (39%) developed serious bacterial infection (VAP or BSI or both) during their stay in ICU. The total mortality rate was 83/118 (70%). The mortality rate due to bacterial infection or a combination of ARDS with bacterial superinfection was 33% (40/118). Six patients had MDR organisms and 34 had XDR (extensively drug-resistant). The dominant species was Acinetobacter baumannii with all isolates (34) being carbapenem-resistant (CRAB) and positive for carbapenem-hydrolyzing oxacillinases (CHDL). One Escherichia coli causing pneumonia harboured the bla(CTX-M-15) gene. It appears that the dominant resistance determinants of causative agents depend on the local epidemiology in the particular COVID center. Acinetobacter baumannii seems to easily spread in overcrowded ICUs. Croatia belongs to the 15 countries in the world with the highest mortality rate among COVID-19 patients, which could be in part attributable to the high prevalence of bacterial infections in local ICUs.
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spelling pubmed-98631232023-01-22 Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb Bedenić, Branka Bratić, Vesna Mihaljević, Slobodan Lukić, Anita Vidović, Karlo Reiner, Krešimir Schöenthaler, Silvia Barišić, Ivan Zarfel, Gernot Grisold, Andrea Pathogens Article During November to December 2020, a high rate of COVID-19-associated pneumonia with bacterial superinfections due to multidrug-resistant (MDR) pathogens was recorded in a COVID-19 hospital in Zagreb. This study analyzed the causative agents of bacterial superinfections among patients with serious forms of COVID-19. In total, 118 patients were hospitalized in the intensive care unit (ICU) of the COVID-19 hospital. Forty-six out of 118 patients (39%) developed serious bacterial infection (VAP or BSI or both) during their stay in ICU. The total mortality rate was 83/118 (70%). The mortality rate due to bacterial infection or a combination of ARDS with bacterial superinfection was 33% (40/118). Six patients had MDR organisms and 34 had XDR (extensively drug-resistant). The dominant species was Acinetobacter baumannii with all isolates (34) being carbapenem-resistant (CRAB) and positive for carbapenem-hydrolyzing oxacillinases (CHDL). One Escherichia coli causing pneumonia harboured the bla(CTX-M-15) gene. It appears that the dominant resistance determinants of causative agents depend on the local epidemiology in the particular COVID center. Acinetobacter baumannii seems to easily spread in overcrowded ICUs. Croatia belongs to the 15 countries in the world with the highest mortality rate among COVID-19 patients, which could be in part attributable to the high prevalence of bacterial infections in local ICUs. MDPI 2023-01-10 /pmc/articles/PMC9863123/ /pubmed/36678465 http://dx.doi.org/10.3390/pathogens12010117 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bedenić, Branka
Bratić, Vesna
Mihaljević, Slobodan
Lukić, Anita
Vidović, Karlo
Reiner, Krešimir
Schöenthaler, Silvia
Barišić, Ivan
Zarfel, Gernot
Grisold, Andrea
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
title Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
title_full Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
title_fullStr Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
title_full_unstemmed Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
title_short Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb
title_sort multidrug-resistant bacteria in a covid-19 hospital in zagreb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863123/
https://www.ncbi.nlm.nih.gov/pubmed/36678465
http://dx.doi.org/10.3390/pathogens12010117
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